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2005
Receptor binding activity
X 0280
(R)-2-(4-Phenylbutyl)dihydrobenzofuran Derivatives as Melatoninergic Agents.
Title compounds (I) and (II) are synthesized as novel melatoninergic ligands with
29- 224 —
significantly lower vasoconstrictive activity in vitro in the rat tail artery. Binding affinity assays are performed on cloned human MT1 and MT2 receptors stably expressed in
NIH3T3 cells. — (SUN*, L.-Q.; TAKAKI, K.; CHEN, J.; BERTENSHAW, S.; IBEN,
L.; MAHLE, C. D.; RYAN, E.; WU, D.; GAO, Q.; XU, C.; Bioorg. Med. Chem. Lett.
15 (2005) 5, 1345-1349; Bristol-Myers Squibb Pharm. Res. Inst., Wallingford,
CT 06492, USA; Eng.) — H. Haber
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