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2005
Pyrazole derivatives
R 0180
Reaction of Indazole with Terminal Di-bromoalkanes and Their Subsequent
Cyclization: A Facile Entry into Fused Indazole Ring Systems. — Ter30- 106 Thermal
minal N-bromoalkylindazoles undergo thermal-induced ring closure in the absence of
solvent to yield fused indazole ring systems. They are of considerable interest in the
design of orally active drugs. — (YANG, J.; GHARAGOZLOO*, P.; Synth.
Commun. 35 (2005) 3, 409-415; Drug Discovery, Purdue Pharma LP, Cranbury,
NJ 08512, USA; Eng.) — H. Toeppel
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