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2005
Fused pyridine derivatives
R 0450
Design and Synthesis of a Potent Macrocyclic 1,6-Naphthyridine anti-Human Cy(HCMV) Inhibitors. — Based on X-ray structure examinations of
30- 131 tomegalovirus
previously synthesized acyclic naphthyridines, novel derivatives such as (VII) are designed. The macrocycles are equipotent compared to the known opened compound.
The structure of compound (VIIa) is determined by X-ray analysis. —
(FALARDEAU*, G.; LACHANCE, H.; ST-PIERRE, A.; YANNOPOULOS, C. G.;
DROUIN, M.; BEDARD, J.; CHAN, L.; Bioorg. Med. Chem. Lett. 15 (2005) 6,
1693-1695; ViroChem Pharma Inc., Laval, Que. H7V 4A7, Can.; Eng.) —
K. Schneider
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