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2005
Receptor binding activity
X 0280
Melanocortin Subtype-4 Receptor Agonists Containing a Piperazine Core with
Aryl Sulfonamides. — Various kinds of compounds such as (I) are syn30- 209 Substituted
thesized. The structure activity relationships are discussed. (Ic) is chosen for additional
in vivo pharmacological experiments since it is the most selective compound and does
not show partial agonism for MC5R. — (FOTSCH*, C.; et al.; Bioorg. Med. Chem.
Lett. 15 (2005) 6, 1623-1627; Dep. Chem. Res. Discovery, Amgen, Inc., Thousand
Oaks, CA 91320, USA; Eng.) — K. Schneider
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