close

Вход

Забыли?

вход по аккаунту

?

код для вставки
2005
Polyphenylalkene derivatives
Q 0740
Unexpected Z-Stereoselectivity in the Ramberg—Baecklund Reaction of DiLeading to cis-Stilbenes: The Effect of Aryl Substituents and
31- 105 arylsulfones
Application in the Synthesis of the Integrastatin Nucleus. — The E/Z-selectivity of
the Ramberg-—Baecklund reaction of various unsymmetrically substituted dibenzyl
sulfones (I) and (VI) is studied. It is shown that for some substitution patterns, an unexpected formation of cis-stilbene derivatives (III) is observed, especially for the o-hydroxyethyl derivatives (Ia), (Ic) and (If). A revised reaction mechanism is presented
which explains all the observed results. The synthetic utility is demonstrated in the
preparation of the integrastatin nucleus (V) on the basis of products (IIa)/(IIIa). —
(FOOT, J. S.; GIBLIN, G. M. P.; WHITWOOD, A. C.; TAYLOR*, R. J. K.; Org.
Biomol. Chem. 3 (2005) 5, 756-763; Dep. Chem., Univ. York, Heslington, York YO10
5DD, UK; Eng.) — Mischke
2005
Документ
Категория
Без категории
Просмотров
0
Размер файла
34 Кб
Теги
1/--страниц
Пожаловаться на содержимое документа