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2005
Pyridine derivatives
R 0380
Regioselective Syntheses of Functionalized 2-Aminopyridines and 2-Pyridinones
Nucleophile-Induced Ring Transformation Reactions. — Direct fusion
32- 139 Through
of pyranones (I) with urea under solvent-free conditions yields both pyridinones (II)
and aminopyridines (III) in a 1:1 ratio, while the reaction in pyridine exclusively provides aminopyridines (III). As for the preparation of aminopyridines, the position 3
functionality plays also a leading role in the preparation of pyridinones (V). Since 3-unsubstituted-2-aminopyridines are difficult to prepare by commonly employed classical
routes, compounds (III) are synthesized selectively using urea as a source of nucleophile which is economical and eco-friendly. — (GOEL*, A.; SINGH, F. V.; SHARON,
A.; MAULIK, P. R.; Synlett 2005, 4, 623-626; Div. Med. Process Chem., Cent. Drug
Res. Inst., Lucknow 226 001, India; Eng.) — H. Hoennerscheid
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