close

Вход

Забыли?

вход по аккаунту

?

код для вставки
2005
Pyrazine derivatives
R 0550
Synthesis of [1,2,4]Triazolo[4,3-α]piperazines via Highly Reactive Chloromethyl— An efficient synthesis of the title compounds using a novel, modular
32- 156 oxadiazoles.
approach. It involves as key step the reaction of a chloromethyloxadiazole with ethylenediamine or unsymmetrical diamines. An excess of diamine is needed to prevent the
formation of by-products. The reaction of (VIII) requires unsymmetrical diamines (V)
and heating to 50 °C. The resulting amidines spontaneously cyclize to afford triazoles
(IX) in moderate yields. — (BALSELLS*, J.; DIMICHELE, L.; LIU, J.; KUBRYK,
M.; HANSEN, K.; ARMSTRONG, J. D. I.; Org. Lett. 7 (2005) 6, 1039-1042; Dep.
Process Res., Merck Res. Lab., Merck&Co., Inc., Rahway, NJ 07065, USA; Eng.) —
R. Steudel
Документ
Категория
Без категории
Просмотров
0
Размер файла
23 Кб
Теги
1/--страниц
Пожаловаться на содержимое документа