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2005
Multi-membered O,S-heterocycles
R 0691
Synthesis of 2-N,N-Dimethylaminomethyl-2,3,3a,12b-tetrahydrodibenzo[b,f]fuDerivatives as Potential Anxiolytic Agents. Part 2. Substitutions
32- 159 ro[2,3-d]oxepine
by Methyl Groups on the Tetrahydrofuran Ring. — The synthesis of a series of
novel tetrahydrodibenzo[b,f]furo[2,3-d]oxepine derivatives substituted by methyl
groups on the THF ring at positions 2 [cf. (X)], 3a [cf. (XIXa)] and 3a,12 [cf. (XIXb)]
and preliminary data on their 5-HT2-receptor affinities are given. The pharmalogical
results show that the structural modifications cause a significant reduction in binding
affinity on both 5-HT2A and 5-HT2C receptors. — (TRABANCO*, A. A.; ALONSO, J.
M.; CID, J. M.; FONT, L. M.; MEGENS, A.; Farmaco 60 (2005) 3, 241-248;
Johnson & Johnson Pharm. Res. Dev., Janssen-Cilag S. A., E-45007 Toledo, Spain;
Eng.) — H. Toeppel
2005
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