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2005
Pyrazine derivatives
R 0550
Synthesis of Some 6,8-Diarylimidazo[1,2-a]pyrazine Derivatives by Using Either
or Microwave Irradiation Method and Investigation of Their Anticancer
33- 178 Reflux
Activities. — A variety of the title imidazopyrazine derivatives (IV) (16 examples) are
synthesized by reaction of diketo compounds (III) with ammonium acetate under both
thermal and microwave conditions. The microwave method is preferred due to higher
reaction rates, cleaner products and operational simplicity. Some imidazopyrazine derivatives display noticeable anticancer activity. The most noteworthy compound (IVd)
is even more active than melphalan against leukaemia. — (DEMIRAYAK*, S.;
KAYAGIL, I.; J. Heterocycl. Chem. 42 (2005) 2, 319-325; Dep. Pharm. Chem., Fac.
Pharm., Anadolu Univ., TR-26470 Eskisehir, Turk.; Eng.) — A. Forchert
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