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2005
Benzoxazole derivatives
R 0230
Synthesis and Antimicrobial Activity of Some 5-[2-(Morpholin-4-yl)acetamido]
5-[2-(4-Substituted piperazin-1-yl)acetamido]-2-(p-substituted phe34- 173 and/or
nyl)benzoxazoles. — In order to enhance the antibacterial activity of previously synthesized benzoxazole derivatives against Gram-positive and Gram-negative bacteria
and the antifungal activity against three Candida species, title compounds (VII) are prepared in which the substitution at the acetamide moiety is changed from phenyl to heterocyclic groups. The heterocyclic ring containing compounds show pretty much increased antibacterial activity against S. aureus and B. subtilis. The newly synthesized
compounds show notable activity against Candida species. However, all compounds
exhibit lower antibacterial activity than the standard drugs. — (TEMIZ-ARPACI, O.;
OEZDEMIR, A.; YALCIN, I.; YILDIZ, I.; AKI-SENER*, E.; ALTANLAR, N.;
Arch. Pharm. (Weinheim, Ger.) 338 (2005) 2-3, 105-111; Dep. Pharm. Chem., Fac.
Pharm., Ankara Univ., TR-06100 Tandogan, Ankara, Turk.; Eng.) —
H. Hoennerscheid
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