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2005
Pyridazine derivatives
R 0500
Synthesis and Benzodiazepine Receptor Affinity of Derivatives of the New TricyHeteroaromatic System Pyrido[3',2':5,6]thiopyrano[4,3-c]py34- 207 clic
ridazin-3(2H,5H)-one. — The new tricyclic systems (VII) and (VIII) are obtained via
condensation of thiopyranopyridinones (I) with glyoxylic acid (II) and reaction of the
intermediate acid mixtures (III), (IV) and (V) with hydrazine or substituted phenylhydrazines (VI). The benzodiazepine receptor ligands display an affinity in the micromolar/submicromolar order, but they show a lower potency than the structurally related
ligands in the benzothiopyranopyridazinone series. — (PRIMOFIORE*, G.; DA
SETTIMO, F.; MARINI, A. M.; SIMORINI, F.; LA MOTTA, C.; TALIANI, S.;
LANERI, S.; TRINCAVELLI, L.; MARTINI, C.; Arch. Pharm. (Weinheim, Ger.) 338
(2005) 2-3, 126-132; Dip. Sci. Farm., Univ. Pisa, I-56126 Pisa, Italy; Eng.) —
H. Hoennerscheid
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