close

Вход

Забыли?

вход по аккаунту

?

код для вставки
2005
Amines
Q 0120
35- 081
Asymmetric Synthesis of α-Monofluoromethyl- and α-Difluoromethylbenzylamines Through Regioselective Hydrogenolysis. — Bis(α-methylbenzyl)amine derivatives (IV) and (VII) are prepared via a dehydration procedure between fluorinated
acetophenones (I) and (V) and α-phenylethylamine (II) followed by asymmetric reduction of partially fluorinated imines (III) and (VI). The diastereomeric excess of (IV) and
(VII) are improved to >99% by recrystallization of their organic acid salts. Opposite
asymmetric induction is observed in the reduction of chiral imines compared to its
non-fluorinated imine analogues. A highly regioselective hydrogenolysis of diastereomerically pure organic salts (VIII) and (X) under the influence of the partially fluorinated methyl group provides an asymmetric synthesis of α-mono- and α-difluoromethylbenzylamines (IX) and (XI), respectively. — (KANAI*, M.; UEDA, K.;
YASUMOTO, M.; KURIYAMA, Y.; INOMIYA, K.; OOTSUKA, T.; KATSUHARA,
Y.; HIGASHIYAMA, K.; ISHII, A.; J. Fluorine Chem. 126 (2005) 3, 377-383; Chem.
Res. Cent., Cent. Glass Co. Ltd., Saitama 350, Japan; Eng.) — H. Hoennerscheid
Документ
Категория
Без категории
Просмотров
0
Размер файла
27 Кб
Теги
1/--страниц
Пожаловаться на содержимое документа