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2005
Oxadiazole derivatives
R 0290
New Oxadiazole Derivatives Showing Partly Antiplatelet, Antithrombotic and
Antagonistic Properties. — Oxadiazole carboxamides (VI) and (XII) in35- 151 Serotonin
corporating lipophilic moieties as well as basic residues are synthesized and tested for
antiplatelet effects in vitro and antithrombotic properties in vivo. 1,3,4-Oxadiazoles
(VI) having a lipophilic biphenyl rest and basic secondary or tertiary amines show antiaggregatory activity when the aggregation is induced by collagen. 1,2,4-Oxadiazoles
(XII) reveal a similar activity pattern. Platelet aggregation induced by serotonin is inhibited by rather small concentrations of (VIb) and (XIIb). Compounds (VIa), (VIc),
and (VId) display little but significant antithrombotic activities. — (BETHGE, K.;
PERTZ, H. H.; REHSE*, K.; Arch. Pharm. (Weinheim, Ger.) 338 (2005) 2-3, 78-86;
Inst. Pharm., FU Berlin, D-14195 Berlin, Germany; Eng.) — H. Hoennerscheid
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