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2005
Fused pyrimidine derivatives
R 0515
Green Chemical Multi-Component One-Pot Synthesis of Fluorinated 2,3-DisubQuinazolin-4(3H)-ones under Solvent-Free Conditions and Their anti35- 181 stituted
-Fungal Activity. — Carrying out the one-pot, multi-component cyclocondensation
with anthranilic acid (I), phenyl acetyl chloride (II), and substituted anilines (III) under
microwave irradiation provides the quinazolinones (IV) without using any dehydrating
agent, solvent or support. This method is applicable even if o-substituted anilines are
employed, in contrast to conventional methods. The shorter reaction time and the easier
work-up are further advantages using this procedure. The quinazolinones are screened
for antifungal activity against three pathogenic fungi utilizing two methods. —
(DANDIA*, A.; SINGH, R.; SARAWGI, P.; J. Fluorine Chem. 126 (2005) 3, 307-312;
Dep. Chem., Univ. Rajasthan, Jaipur 302 004, India; Eng.) — H. Hoennerscheid
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