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2005
Purine derivatives
R 0540
Synthesis, Biological Studies and Molecular Modeling Investigation of 1,3-Dime1,2,3,4-Tetrahydro-[1,2,4]-triazo36- 158 thyl-2,4-dioxo-6-methyl-8-(substituted)
lo-[3,4-f]-purines as Potential Adenosine Receptor Antagonists. — A new series of
potential adenosine receptor antagonists having a triazolopurine structure are synthesized and evaluated for their adenosine receptor binding affinities. All the synthesized
compounds are found to be completely inactive at all four adenosine receptor subtypes
independent of their substitution pattern. — (PASTORIN, G.; BOLCATO, C.;
CACCIARI, B.; KACHLER, S.; KLOTZ, K.-N.; MONTOPOLI, C.; MORO, S.;
SPALLUTO*, G.; Farmaco 60 (2005) 4, 299-306; Dip. Sci. Farm., Univ. Trieste,
I-34127 Trieste, Italy; Eng.) — A. Forchert
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