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2005
Fused pyrimidine derivatives
R 0515
Synthesis and Isomerization of Thienotriazolopyrimidine and ThienotetrazolopyDerivatives with Potential Antiinflammatory Activity. — The synthesis
37- 156 rimidine
of several derivatives of the thienotriazolo[4,3-c]pyrimidine system [cf. (VII)] and their
isomerization into thermodynamically more stable thienotriazolo[1,5-c]pyrimidines
[cf. (VIII)] as well as the preparation of thienotetrazolopyrimidine (XI) are described.
Compounds (VII) and (XI) are tested as potential antiinflammatory agents. Derivative
(VIIb) shows a potent activity in the carrageenan test. — (RASHAD*, A. E.;
HEIKAL, O. A.; EL-NEZHAWY, A. O. H.; ABDEL-MEGEID, F. M. E.; Heteroat.
Chem. 16 (2005) 3, 226-234; Dep. Photochem., Natl. Res. Cent., Dokki, Cairo, Egypt;
Eng.) — H. Toeppel
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