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BY (11) 8770
(13) C1
(46) 2006.12.30
(19)
(12)
7
(51) C 07D 213/26, 213/61
2-
(54)
(21)
(22) 2004.03.03
(43) 2005.09.30
(71)
:
-5-
: a 20040166
(73)
"
-
" (BY)
"
-
(56) US 4990622, 1991.
EP 722933 A1, 1996.
US 5442072 A, 1995.
US 5198549 A, 1993.
JP 5-221987 A, 1993.
JP 10-87624 A, 1998.
" (BY)
(72)
:
:
;
;
;
(BY)
(57)
2-
-5CH2Cl
Cl
BY 8770 C1 2006.12.30
2,
,
N
-5,
-
.
,
2-
-5-
-
1:
CH2Cl
Cl
2-
-5-
N
1
,
,
,
[1].
CH2Cl
CH3
Cl2
Cl
N
2
Cl
N
1
-
BY 8770 C1 2006.12.30
2-
1
2
-5-
60 °
265 %
10
-5-
1.
-
[2, 3].
.
2-
2,
222-
-5-
-5-5-
2.
1
2
[4].
2-
-5-
1
2-519,2 % 0,4 %
68 %,
2.
-5-
-5-
,
22,
,
2-
-5-
-5-
1
,
.
CH2Cl
CH2OH
SOCl2
Cl
Cl
N
N
1
3
1
3
[5-7].
-
3,
.
CH2Cl
CH2OH
PCl5, POCl3
96%
O
N
H
Cl
N
1
4
2-2[8].
-5-
1
5-
4
1
[8]
96 %.
5-
-5-
4
-
.
CH2Cl
CH2OH
PCl5, POCl3
95%
HO
N
Cl
N
1
5
25
2-
[9].
95 %.
6-
2-
-5-
1
-5-
2-
1
5
-5-
.
2
-5-
BY 8770 C1 2006.12.30
22-
5
.
CH2NHBz
BzCl, Et 3N
CH2Cl
COCl 2, HCON(CH3)2
Cl
N
1
-56-
CH2NH2
Cl
-5-
N
6
Cl
N
7
2-
1
-5-
1
6 [10, 11].
-
6
N7.
,
55,6 %
7
(
2-
.
),
-5-
1.
[10, 11]
N-
,
,
.
[10, 11]
-
6,
1
.
CH2Cl
CH2OH
COCl2, HCON(C4H9)2
Me O
88%
N
Cl
N
1
8
2) [12].
8(
2-
-5-
-5-
1
21
-5-
-
8
,
.
.
[12]
2-
-5-
1
88 %.
(
) [12]
.
-
,
.
,
-
,
,
.
-
,
.
,
-5-
2-
22-
-5-5-
[12],
8.
2-
1
8
.
3
-5-
1.
1.
-
BY 8770 C1 2006.12.30
CH2Cl
CH2OH
SOCl2, HCON(CH3)2
Me O
88%
N
Cl
N
1
8
2,
-5) [12].
(
1
-
,
,
.
2-
-
-5-
8
,
-
.
2-
-5-
1
,
.
,
,
,
.
.
21
-5-
.
.
19,37
)
(0,14
40
) 236,64
-5(0,308
8
)
2,05
(0,028
30
1,5 .
2 ,
,
100
, pH
5 %-
7-8
,
5
,
.
30
(3x30
,
,
),
19,84 2-51.
88 %. T.
. 88-91 ° /2
.,
.
. 70-80 ° /1
. [8, 12].
((CD3)2SO, δ,
.): 4,85 (2 , , CH2Cl),
7,57 (1H, , J 8,5 , -3), 7,95 (1H, , J1 8,5 , J2 2,5 , -4), 8,50 (1H, , J 2,5 , -6).
4
.
BY 8770 C1 2006.12.30
:
1. Yamamoto I., Casida J.E. Nicotinoid Insecticides and the Nicotinic Acetylcholine Receptor. Tokyo: Springer-Verlag, 1999. - 300 p.
2.
4778896. Process for the preparation of 5- hloromethylpyridines / B. Gallen
kamp.
3.
3630046. Verfahren zur Herstellung von 5-Chlormethylpyridinen / B. Gallen
kamp.
4.
5324841. Method of chlorinating side chain of 2-chioro-methylpyridine /
Y.Nishimura, Y. Itou, A.Morino, K.Nishihara, S.Kawamura.
5. Tilley J.W., Levitan P., Kierstead R.W. Synthesis of heterocyclic analogs of α- methyldopa // J. Heterocycl. Chem. - 1979. - Vol. 16. - No 2. - P. 333-337.
6.
5489603. Guanidine derivatives, their production and insecticides / H. Uneme,
K. Iwanaga, N. Higuchi, I. Minamida, T. Okauchi.
7.
4576629
. Herbicidal thiadiazole ureas/ R.B. Morland, A.R. Cooke, J.R. Bishop.
8.
4958025
. Preparation of 2-chloro-5-chloromethylpyridine / K. Jelich.
9.
6022974. Process for the production of 2-chloro-5-chloromethyl-pyridine /
O. Werbitzky, P. Studer.
10.
0722933. Verfahren zur Herstellung von Chlormethylpyridin Derivatives und Acylaminopyridine als Zwischenprodukte/ Lantzsch R.
11.
5623076. Process for the preparation of chloromethylpyridines/ Lantzsch R.
12.
4990622. Process for the preparation of 2-chloro-5-chloromethylpyridine /
K. Jelich. (
).
.
220034, .
,
.
, 20.
5
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