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Патент USA US2105197

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Patented Jan. 11,, 1.938
2,105,197
UNI-TED STATES PATENT o'rrilca
2,105,197
MEDICAMENT
Adelia McCrea, Detroit, Mich, assignor to Parke,
'
Davis & Company, Detroit, Mich, a corpora
tion of Michigan
'
No Drawing.
,
Application July 13, 1931,
Serial No. 550,630
7 Cs. (6]. 167-63)
The invention relates to a therapeutic agent small amounts of essential oils or other materials
useful in treating certain fungous infections such for imparting a pleasant odor to the mixture.‘
as dermatomycosis, epidermomycosis and epi
An example of a prefered formula is as follows:
dermophytosis. This disease is very common
5 throughout the entire world and is often referred ‘
Per cent
5
Lanolin _______________________________ __ _80
to as “athlete's foot-itch”, “dhobie itch”, “jockey
.‘strap itch”, etc. It is caused by certain fungi Water ___________________________ _. ____ __ l0
among which Trichophyton interdigitale is one Petrolatum ____________________________ .. 9
of the most resistant forms.
10
-
White wax _____________________________ __
My invention resides in the discovery of a new
6
Chlorbutanol (trichlortertiary butyl alco
‘ class of medicaments for the treatment of the
hol) _________ __'______________________ __
5
above mentioned disease and more particularly
to certain compositions for eliminating the fun
gous infection without causing pain or irritability
15 of the infected tissues.
Salicylic acid __________________________ __
Mercury salicylate _____________________ __
4
4':
The therapeutic agent made in accordance with
my invention contains in its preferred form at
least two main ingredients; ?rst a material for
keratolyzing and desquamating the tissues of
20 fungous lesions, and second a material for re
lieving the irritation caused by the kerotolyzing
and desquamating action.
The ?rst material may be selected from a wide'
variety of substances such for example as: Sali
25
cylic acid, mercury salicylate, phenols, tar oint
ment, benzoic acid.
The above materials may be used either singly
or in suitable combinations.
‘
‘It is also to be understood that other substances
30 may be-substituted for those’ listed providing
they have the required kerotolyzing and desqua
mating properties.
-
The second material of the formula may be
selected from three or more diiierent classes, all
of which are of an anesthetic nature and are
capable of reducing the irritability caused by
'keratolyzing and desquamating.v One of the
' classes comprises materials which are merely
anesthetic in their action such as butyn, novo
A second class comprises materials
which are not only anesthetic but also fungistatic
agents such as chlorbutanol and brombutanol.
The third class comprises materials that are fun
gicidal as well as mild anesthetic agents and
includes such materials as the high molecular
40 caine, etc.
Sodium citrate _________________________ __
1
Oil of cloves ___________________________ __
Oil of cinnamon _______ _'_ _______________ __
0.5
0.5
100
Another formula coming within the purview of
the invention is:
20
‘
Per cent
Lanolin ____'______\ _____________________ __ 60
Water _________________________________ _- 10
Petrolatum ____________________________ __ 9
White wax ______________ __‘_ ____________ __
25
Chlorbutanol (trichlortertiary butyl alco
hol) _________________________________ __
5
Salicylic acid __________________________ _.
Benzoic acid _____ __' ____________________ ...'.
3
5
Sodium citrate ________________ _; _______ __
1
Oil of cloves ___________________________ __
0.5
-
Oil of cinnamon ____ _; __________________ __
0.5
30
100
Another modi?cation of the invention contains:
Per cent
,Phenol _________________________________ __ 2
Zinc oxide ________ _-; ___________________ __ 20
Tar ointment ___________________________ __ 23
Ointment of rose water__________________ __ 50
Chlorbutanol ____ __ _______ __, _______ -s ____ __-
5
100
In
the
speci?c
examples
given
above
the
com
weight phenols and polyhalogenated phenols.
ponent for reducing irritability of the mixture
‘ Examples are trichlorphenol, tribromphenol and
is chlorbutanol. However, it is to be understood
bromnaphthol, etc.
'
In preparing a therapeutic agent in accordance . that, other materials as heretofore listed may be
.
with my invention suitable proportions of the' substituted for the chlorbutanol.
In certain broader aspects, my invention con
two main ingredients above discussed are com
sists in the discovery that chlorbutanol and other
bined preferably in a suitable carrier adapted to halogenated
tertiary butyl alcohols have a fun
form a salve. The carrier may be selected from gistatic action on Trichophyton interdz'gitale and
such materials as lanolin, wax, petrolatum, cocoa other fungi which cause dermatomycosis, epi
55 butter, etc., and usually has incorporated therein
10
dermomycosis and epidermophytosis and are
.
9,108,197
2
. bene?cial in inhibiting proliferation of the fun
gus causing "athlete's foot-itc ".
Thus it comes within the purview of. the in
vention to incorporate chlorbutanol and its equiv
alent homologues in any therapeutic agent for
the topical treatment of fungus infections of the
type of dermatomycosis, epidermomycosis and
epidermophytosis where the newly discovered
“ properties may be used for combating Trichophy
10 ton interdz‘gitctle and other fungi causing der
matomycosis, epidermomycosls and epldermophy
tosis.
What I claim as my invention is:
1. A therapeutic agent for treatment of fun
15 gous infection of the type of dermatomycosis, epi
dermomycosis and epidermophytosis comprising
an ointment base, salicylic acid, mercury salioyl~
ate and chlorbutanol.
2. A therapeutic agent for treatment of derma
20 tomycosis, epidermomycosis and epidermophyto
siscomprising a keratolyzing and desquamating
agent of the class consisting of salicylic acid, mer
cury salicylate, phenols, tar ointment and ben
zoic acid and a material incorporated therein of
25 the class consisting of butyn, novocaine, chlor
butanol, brombutanol, trichlorphenol, tribrom
phenol and bromnaphthol.
'
3. A therapeutic agent for the ‘topical treat“
ment of fungus infections of the type of derma
30
tomycosis, epidermomycosis and epidermophytosis
comprising a salicylic acid compound having a
keratolyzing and desquamating action and a
halogenated tertiary butyl alcohol capable of re
lieving the irritation caused by said salicylic acid
35 compound at the site of said fungus infections
and having a fungistatic action on said fungus
infections.
4. A therapeutic agent for the topical treat
ment of fungus infections including Triciwphyton
interdioitale and other fungi causing dermato
mycosis, epidermomycosis and epidermcphytosis
comprising a salicylic acid compound having a
lzeratolyzing and desquamating action and chlor
butanol capable of relieving the irritation caused
by said salicylic acid compound at the site of
said infections and having a fungistatic action on
said infections.
5. A therapeutic agent for the topical treat
‘ment of fungus infections of the type of derma 10
tomycosis, epidermomycosis and epidermophyto
sis comprising an ointment including lanolin,
petrolatum. and wax, a keratolyzing and des
quamating agent including salicyclic acid and
mercury salicylate and chlorbutanol in amount 15
su?cient to relieve the irritation caused by said
keratolyzing and desquamating agent at the site
of said fungus infections and having a fungistatic
action on said fungus infections.
6. A'therapeutic agent for the topical treat 20
ment of fungus infections of the type of derma
tomycosis, epidermomycosis . and epidermophyto
sis having substantially the following composi
tion:-lanolin 60%, water 10%, petrolatum 9%,
white wax, 6%, chlorbutanol 5%, salicylic acid 25
4%, mercury salicylate 4% and sodium citrate 1%.
7. A therapeutic agent for the topical treat
ment of fungus infections including Trichophyton
interdigitale and other fungi causing dermatomy
cosis, epidermomycosls and epidermophytosis
comprising an ointment base, a salicylic acid
compound having a keratolyzing and desquamat~
ing action and chlorbutanol in an amount on the
order of 5% having fungicidal action on Tri
chophyton interdigitale and having anesthetic
action adapted to counteract irritation caused by
- said salicylic acid compound.
I ADELIA McCREA.
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