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Патент USA US2115040

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2,115,046
Patented Apr. 26, 1938
v
UNITED STATES PATENT OFFICE
2,115,040
PROTECTION OF VITAIWINOUS OILS
Ferdinand W. Nitardy, Brooklyn, N.'Y., assignor
to E. R. Squibb & Sons, New York, N. Y., a cor
poration of New York
No Drawing. Application August 15, 1934,
Serial N0. 739,929
.
,
19 Claims.
This invention relates to the protection of vita
,
(CI. 99-11)
as a solute is made possible, and the protection
' minous oils, particularly with respect to vitamin
of the oils is correspondingly enhanced, by adding
content and palatability.
Hydroquinone has been recognized by several
5 investigators as useful in checking the deteriora
to the oils a ‘carrier which is miscible with the
oils and in which the hydroquinone is more sol
uble than in the oils.
_ " '
Among the suitable carriers are those in the
tion to which the vitamins of ?sh-liver and vege
table oils, and the oils proper, are subject on ex I class embracing alcohols,'aldehydes, ethers, esters,
essential oils, and essential-oil fractions. Speci?c
posure to‘ oxygen. Hitherto the role of the hydro
examples include ethyl alcohol (absolute), nor
quinone has been deemed to be a species of nega
mal-propyl
alcohol,‘ isobutyl alcohol, benzyl alco-v
tive
catalysis;
or
at
any
rate
it
has
been
thought
10
that dissolving in the oils a small proportion, less
than or no more than the saturation amount, of
hydroquinone could be relied on as a method of
securing adequate‘ protection for an unlimited
' time.
Experience has shown, however, that this
method of treatment cannot be depended on to,
- safeguard the oils for the many months that
hol, isovaleraldehyde, salicylaldehyde, cinnamal
dehyde, dimethyl ether, diethyl ether, ethyl ace
tate, ethyl butyrate, methyl salicylate, spearmint
oil, peppermint oil, menthol. Oxidizing materials
should of course not be present in the carriers, 15
as peroxides in diethyl ether. Some carriers, on
account of giving an unpleasant taste, may be un
suitable for use in oil to be drunk but satisfactory
often pass between the packaging of the oils and
their consumption; on the contrary, oils to which for capsuled oil. On the other hand, essential
an addition of this kind has been made su?fer a oils, besides acting as carriers, are preferred for 20
considerable vitamin loss, as well as a degradation ' the agreeable ?avor they impart.
Among the oils to which the invention is ad
of taste and odor, during the course of storage,
vantageously applicable are halibut-liver oil, cod
especially if the oils encounter ‘conditions parti
cularly favorable to oxidation and/or if they are liver oil, sword?sh oil, various other ?sh and ?sh-'
contained in vessels pervious to air, like gelatin
An object of this invention is the provision of
a method whereby vitaminous oils may be af
forded protection to a higher degree and/or for a
30 longer period than has been possible by methods
hitherto employed. A further object is the pro
vision of vitaminous oils endowed with such pro
tection.
liver oils, and vegetable oils.
25
By means of such carriers, vitaminous oils are
capsules.
_
‘It has been found that the hydroquinone func
tions more or less quantitatively, that it becomes
‘progressively inactivated with lapse of time, that
its preservative e?ect increases with its concen-_
tration, and that vitaminous oils dissolve it too
scantily-thus, a saturated solution of hydro
40 quinone in halibut-liver oil at room temperature
has a concentration of only about 0.03 percent,
~to be protected thereby su?iciently to meet the
enabled to hold extra hydroquinone in solution
and in consequence to withstand for longer pe
riods and/or‘under more adverse conditions the
deteriorative effects of oxygen on the vitamins 30
and on the oils proper. Thus, the physical,
chemical, and therapeutic stability of halibut
llver oil is raised to a point where it gives full as
surance for ordinary circumstances, by increas
ing its hydroquinone content in this manner to 35
about 0.1 percent.
.
.
Introduction of the hydroquinone may be ef
iected by mere admixture of the oil with a solu
tion of the hydroquinone in the carrier. Thus,
0.05 to 0.2 g. hydroquinone may be dissolved, with 40
gentle warming if necessary, in 0.5 to 3.0 cc. of
not uncommon commercial exigencies. It was
the carrier selected, and the solution may be well
mixed with enough of the oil to make a total
accordingly necessary to incorporate extra hydro
volume of 100 cc.
quinone (by which is meant herein hydroquinone
‘
Addition to 100 cc. halibut-liver oil of 2 cc. 45
in excess of the concentration the vitaminous oil absolute alcohol containing in solution 0.1 g.
alone- would dissolve at room temperature) into ' hydroquinone or 5 cc. absolute alcohol contain
the oil; and since solids would be less active than _ ing in solution 0.3 g. hydroquinone, yields, respec
dissolved substances and since the ‘presence of tively, a 0.1 percent or a 0.3 percent solution of
solids, as depositsvor sediment, would be objec
tionable in oils intended for internal use, it was
hydroquinone in halibut-liver oil.
a
‘
50
Mixture of 80 cc. halibut-liver oil with v5 cc.
also necessary to incorporate the extra hydro- V peroxide-free diethyl ether in which 0.4 g. hydro
quinone into the oil as a solute.
In the practice of this invention the incorpo
55 ration of extra hydroquinone into vitaminous‘ oils
quinone has been dissolved, gives a concentra
tion or 0.5 percent, which may be reduced to
any desired degree by addition of more oil.
65
2
2,115,040
A 0.05 percent solution my be produced by
5. Vitaminous oils containing extra hydro
dissolving 0.05 g. hydroquinone in 0.5 cc. nor
quinone and a. carrier which is miscible with the
.mal-propyi alcohol, isobutyl alcohol, or ethyl _ oils and in which the hydroquinone is more.
acetate, warming ii‘
, and adding the soluble than in the oils.
solution to 100 cc. halibut-liver oil.
6. Vitaminous oils containing extra hydro
Dissolving 0.005 :- hydmquinone in 0.05 g.
10
quinone and spenrmint oil, the latter being a.
cinnamnldehyde, ethyl butyrate, peppermint oil,
carrier for the former.
or menthol, and adding the solution to 10 cc.
halibut-liver oil, secures a 0.05 percent concen
'7. Vitaminous oils containing extra hydro
quinone and an ether, the latter being a carrier
trationoi'thehyrlroquinoneintheoil; and
doubling the weight: 01 the hydroquinone and the
carriers raises the
on to 0.1 percent.
By slightly warming 0.05 g. hydroquinone with
0.68cc.olinndaddingthesolutionto
100cc.hniibnt-liverolithexeisobte.ineda0.05
‘
»,;
for the former.
10
8. Vitaminous oils containing extra hydro
’quinone and'enrvalcoholrthe‘ietteribein’g 1: car
rier for the former.
9. Halibut-liver oil containing extra. hydro
quinone and a carrier which is miscible with the
halibut-liver oil and in which the hnimquinone
- is more soluble than in the halibut-liver oil.
10. Halibut-liver oil containing extra hydro
quinoneandspearmintoiLtheletterbdnge
not. Byemployingll?gorhlghydroquinone
insteodofo.05g.,nndincrensingtheamountof
aieumintoliiinecelsu-y,iybigher
concentrations oi’
cured.
may be ac
'
Itistobennderltoodthntthei'ex
nmplesnremereiyilhutntivenndbynomeens
limitn?veotthe_imcn?on,whichrnsybeva
nously'ctherwlsewithrcspectto
carrier for the former.
11. The method of enhancing the protection
of vitaminous oils that comprises incorporating
extra. hydroqulnone therelnto as a solute with
the aid oi.’ an essential oil.
~‘
~
12. Vitaminous oils containing extrn hydro
quinone and an essential oil, the latter being a
carrier for the former.
,
13. Vitaminous oils containing extra hydro
- quinone and diethyl ether, the latter being a,
4 carrier for the former.
1
-
14. Vitaminous oils containing extra, hydro
30
quinone and ethyl alcohol, the letter being n car
rier for the former.
'
_
A
15. mint-liver oil conteiningextrn, imiro
quinone andan essential oil, the latter being a, 35
carrier for the former.
16. Halibut-liver oil conteinim extra hydro
quinone and an ether, the latter being a carrier
for the former.
_
‘
17. Halibut-liver oil containing extra, hydro
mthereintolsnloiutewiththe
_
aidofspeumintdl.
3.1hemethcdoi’enhnndngtheprotection ot
dlstintcomnrlses-ex
tratherclntonsnsolutewith the
nldoinnether.
immethodoi'enhnndngtheprotection of
Iitnminonsoilsthat comprises incorporating ex
iz'athereintoasnsolute with the
nidoinnalcohoi.
quinone and an alcohol, the latter being a cer
rier for the former. _
18. Haiilmt-iiver oil-containing extra hydro
quinone nnddiethylether,thelatterbeingncar-'
ri'er for the former.
v19. Halibut-liver oil containing extra hydro
quinone and ethyl alcohol, the latter being-n cer- '
rier for the former.
'
FERDINAND W. NITARDY. ,
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