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Патент USA US2115731

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May 3, 1938.
M. LOZIER’ETAL‘ ’
~
v 2,115,731
' MULTIPLE COMPARTMENT AMPULE AND HYPODERMIC VSYRING‘E
Filed Feb. 4, 1957
‘
NA 7'7'HEW LOZ/E'Ri v
> CLAY TON />-/. FROJ 7' '
INVENTORS
ATTORNEY
Patented ‘May3, 1938
. $2,115,731
UNITED STATE 8‘ PATENTQOFFICEY
2,115,731
MULTIPLE COMPABTMENT .AMPULE AND
,
~
_
,
HYPODEBMIG
SYRINGE
,
,
~
Matthew Loller, Brooklyn, N. Y.,‘ and Clayton H;
Frost,v Union, N. Insulators,‘ byxdirect and _ ‘
meme assignments, to Cook Laboratories, Inc.,
New York; N. Y.,>a corporation of Delaware
Application February 4, 1931, Serial No."124,0l0: '
'
80mm.
(01.1287-215)
This invention relates to a- multipl'epcompart
drawn.‘
An object of this invention is to provide, a‘
5 container ‘having separate compartments con
taining dissimilar ingredients, the said compart
ments‘ being de?ned by spaced stoppers of pierce
able material and‘ which are slidably positioned
10
"
view- of ‘our double compartment “ampule, com- 5
prising an elongated tubular outer member or
casing“ preferablyv made of glass?and having‘
a pluralitylof disk-shaped stoppers I2, I21 and
_V v
.
_
.'
tion" the numeral III .‘indicates a cross-sectional. ,
Another object of this invention is to provide
a multiple compartment ampuie which may be
inserted into a hypodermic syringe for surgical
or dental use.
.
‘In the illustrated embodiment oi the_inven
‘
in. the container.
r
discharged'and shows the piercing element with-l
ment ampule and to a hypodermic syringe de
signed for use with said ampule.
-
I!2 inserted. "Thestoppers vare preferably made _
of a' yieldable material such as rubber, and are 10
of suillcientlylarge external‘. diameter to friction
allg engage the internal diameter of the tubular
member llv in sealing relation.
I
Another object of this invention is- to'provide
15 a hypodermic syringe having a plunger with a
piercing element, the said element having a chan
_
v
'
Figure vl shows the ampule with the stoppers
positioned therein in “spaced relation so was to 15'
form two compartmentsv i3, H, which may con- -
'
dissimilar liquids ‘and is hermetically "sealed'_
nel designed to provide communication between ' tain
the compartments in the said ampule when the from eachother by the disks i21 due to its fric?
piercing element is pushed through adjacent’ tional sealing engagement‘ in the, tubular mem
ber ii. ‘It will be noted ‘that in Figure l'the 20
20 stoppers.
with the ‘above and other objects in view, the disk I! vis positioned ator ‘near one end i5 of
invention‘ will be hereinafter more particularly the tubular member ii," andthat'the disk‘ l21_
is spaced at a predetermined distance ‘therefrom
to form the compartment 13, whilev the'disk I23
has been positionedinwardly from the end l?f'of 25
25 form part of thisjspeciilcation.
Reference will now be had'to the drawing,j the tubular member "so as to form thel'closed"
compartment’ i4.;-,'I'his position of ‘the disk i22
wherein like numerals of reference designate cor
described in connection ‘with the accompanying
drawing and pointed out in the'claims which
the end it and‘ the stopper I21 is gov-‘l ~
responding parts throughout the-several views, between
emed by the length or; the compartment [3. 'The ‘
in which:
30
'
'
'
'
j
Figure 1 is a central longitudinal cross-sec
tional view of our multiple compartment ~ampule'
having disks in predetermined spaced relation
therein, and being designed for surgical or dental
use, in conjunction with a hypodermic syringe
36 having a piercing element designed for the pur
pose, the ampule being shown on an enlarged
scale.
‘
Figure 2 is a cross-sectional view or a frag
mentary portion of the ampule with the piercing
40 element inserted in two adjoining disks therein
and with the said disks remaining in the posi
tion shown in Figure l.
'
Figure 3 is a cross-sectional view ‘of the'a'm
pule after the liquid in one compartment has
45 been transferred into the other compartment;
and shows the piercing element inserted through
two adjoining disks in the ampule.
'
length of the open end space'is substantially the 80,
same as the length of the compartment IS. The
end space is essential to permit the movement »
of- the‘ disk l2" when the liquid in the compart
ment i3 is transferred into the compartment i4. I
For" the purpose of our inventiom all the stop- 85 ’
per'smust be positioned entirely inside‘ and fric
tionally slidable in the tubular member N. Fig
ture I shows the ampule' ill with three stoppers
or disks of the same diameter throughout‘ their
length positioned‘ before the liquid in the con'i'-' 4°
partment i! has been transferred into the come‘
partment
l4.
'
1
'
-
_
j
,
Figure 2 'shows a iragmentary portion of an
ampule iii having the piercing element 20 of a,
hypodermic syringe-plunger inserted in’ the disks ‘5
l2
and
I21.
_
v
"
‘
i
"
'
Figure 3 shows a cross-sectional view of ' an am
pule l0 having the piercing‘ element 20 “inserted,
able plunger having the piercing element and in the disks l2 and-I21 ‘and'the said disks vmoved
Figure 4‘ shows a fragmentary'portion of a slid
50 forming part of a hypodermic syringe shown in
Figure 5.
'
Figure 5 is a plan view of a hypodermic syr- Q
. inge adapted for use with our multiple com
partment ampule, showing all the disks in‘po
inwardly
Figure 4ofshows
the casing
a fragmenta'
‘l I‘.
1 portion
t
of the
plunger I'I forming part of the hypodermic sy'ringe i8 shown‘in Figure 5'. It will be'noted that
the head I! of the plunger l'l has secured there
66 sition when the- liquid in the ampule has been ' to a hollow‘piercing‘ element 20 having a sharp 55
2
2,116,781
and tapering end portion 2| and an axially po
sitioned channel 22 adapted to communicate with
an aperture 25 in the side of the element 20.
As will be'seen from Figures 1 and 4 the ap
erture 25 is positioned from the head or collar
I 9 a distance substantially equal to the thick
ness of the-enddisk l2.
_
_-
described and illustrated the preferred embodi
ment of our invention, but it will be understood
that various changes and modi?cations can be
made therein without departing from the scope
oi.’ the invention as de?ned by the appended
claims.
-
Due ‘to the""sharpness oi’ the piercings-element
and the frictional resistance of‘ the disks l2, I21
10 and I23 in the tubular member Ii, it is possible
‘We-claim:
.
g
.
l
.
1. In a multiple compartment ampule: oi’ the
class described comprising a tubular outer mem
her and three spaced disks irictionally secured in
to pierce the stoppers or disks l2 and I21 by
relation therein to form separated liquid
exerting manual pressure against the handle '23 _ sealing
compartments hermetically sealed from each
of the plunger l1 without altering the position other,
said disks being at least partially centrally
of the said disks. It is to be notedthat the
15 piercing element 20 may also be ‘utilized-inde- ' intact and being pierceable, all of said disks being
pendently oi’ the plunger of the hypodermic syr-' 01' .the same diameter throughout their length and 15
being entirely. inside said tubular member, two
"
‘
said'disks being in closely spaced relation at
When the compartments Ill and I4 contain ‘ of
one end and one oi’ said disks being positioned in
liquids, due to the incompressibilityoi the liquids, wardly
oi the opposite end to form an open space
inge I8.
20 when further pressure is exerted against the
plunger I‘! it will cause the disk 12 to be moved
into contacting relation with the disk "1' ‘and
the disk I22 to move simultaneously and equally
to the end II of the ampule Ill, since the channel
26 22 in the‘ piercing element 20 connects the co -
partments l3 and I4 and permits transfer of the
at said end, the length of said end space being
substantiallythesame asrthe distance between
said closely spaced disks, said end space being
substantially ?lled bysaid inwardly positioned
disk by outwardv movement thereof to permit
transi'errence of the liquid from the compartment . 25
liquid from the compartment ll into the com-j between said closely spaced disks into the length
ened ‘adjacent, compartment .when said, closely
Dartment II. It is to be noted that both end disks spaceddisks are successively perforated, both end
l2 and I2’ are movable simultaneously and equally disks being movable simultaneously and equally
30 ‘while the ‘intennediate disk I 21 remains ?xedv dur-,
while the intermediate disk remains ?xeddurin‘g 30
ing said liquid transferrence.
, v
,.
Further outer movement 01' the disk I 2:I is pre
vented by the front inner end of. the hypodermic
syringe la in which the ampule"! may be con
?ned ‘during the trar‘lsi'errlng operation. _
'
Further movement oi’ the plunger I‘! will cause
the discharge of the combined liquids from the
compartment II when the inner end of a hypo
dermic needle 24 passes through the disk I21.
As shown in Figure l, the disk I 22 has a cavity
28, to permit the piercing element to enter there
inand thus allow the disk I21 to get into substan
tially contacting relation withthe disk l22 in the
position when the element I‘! has already
through the disks I2 and l21~and the ampule has
been discharged of its liquids.
. '
It is to be noted. that while it is preferable to
‘provide a cavity in the disk III, as above men
tioned, it is possible for the ampule to be operable
50 when the disk I22 is without a cavity. Also when
the disks l2 and I21 are provided with cavities
similar to cavity 26.
.
rIt is to be noted that when the compartments
II and ill contain liquids, thatall three separa
tors will move during the‘ discharging operation.
However, when one of the ingredientsis in pow
der form or semi-solid form only two of the
separators will be moved.
‘
.
It is also to, be, noted that while we havedis
closed separators in solid disk form and also in
a form showing a cavity in the disk, that, these
separators may ‘take the form of cup washers
(not shown).
}
It is also to be noted that the gist 01’ our inven-_
65 ; tion is to make it possible to bringsdissimilar
ma
terials con?ned in separated compartments into
said liquid transi'en'ence.
.
‘
I
2. A multiple compartment ampule having a
plurality of 'disks and being adapted for use in a
syringe having two needles for piercing the'disks'
from opposite ends of said ampule, comprising a' 35
tubular outer member and three spaced‘ disks
frictionally secured in sealing relation therein‘ to
form
separated / compartments hermetically
sealed from each other, two oi'sai‘d" disks being
respectively‘ positioned substantially at the ends
of said tubular member and one of said disks be
ing positioned in spaced .relation' between said
end disks, one of said end disksbeing at one end
of said tubular member and the other end disk
being positioned inwardly'oi- the opposite end to
form an open space at said end-said open space
being substantially closed by said inwardly po
sitioned disk during operation of said ampule.
3. A multiple compartment ampule oi’ the class
described. comprising a ‘tubular outer member
and three spaced 'disksirictionally secured in
sealing relation therein to form separated com
partments hermetically sealed from. each other.
all of said disks being pierceable and normally
imperiorate, all 01' said disksbeing oi’ the same
diameter throughout their length and being en
tirely inside said tubular member, two of said
disks being in closely spaced relation at one end
and one of said disks being positionedinwardly
oi the opposite end to form an. open space at said
end, the length oi’ said end space being substan;
tially the same as the distance between. said close-2
ly spaced end disks. said end space being substan
tially ?lled by outward movement of said inward,
ly positioned disk during said transierrence when
said closely spaced disks are successively perfo
rated, both end disks being movable simultane
ously and equally while the intermediate disk re
casing Ii ; it is, however, within the scope of our, mains
?xed during said liquid transferrence.
70 invention to house the dissimilar materials in in
4. A multiple compartment ampule having a
dependent casings and to join them into opera plurality
of disks and being adapted for use in
tive relation (not shown) so as to carry out the a syringe having two needles for piercing the
objects oi’ ourinvention which are carried» out in disks from opposite ends of said ampule, compris
the embodiment shown.
a tubular outer‘ member and a plurality of
76
In accordance with the patent statutes we have ing
spaced disks irictionally. secured in‘sealing rela 75
contacting relation. As shown in Figure 1, the
separated compartments l2 and I4 are in one
3
9,115,781
element, a collar ?xed to said piercing element,
said lateral inlet means being spaced from said
collar a distance substantially equal to the thick
tlon ‘therein to form separated compartments
hermetically sealed from each other, all of said
disks being of the same diameter throughout their
length and being entirely inside said tubular
member, two of said disks being in close relation
at one end and one of said disks being positioned
inwardly of the opposite end to form an open
space outside the disk at said end, said open space
being substantially ?lled by said inwardly posi
tioned disk during operation of said ampule, and
said disk having a cavity in one face thereof. a
5. In combination with a ‘multiple compart
ment ampule of the class described, a hypodermic
ness of the end disk to be initially penetrated.
,
7. In combination with a multiple compart
ment ampule ‘of the class described, a piercing
element having one piercing end and a collar at
the end opposite the piercing end, 'said element
having a channel positioned axially thereof, said
channel having inlet means laterally and inter 10
mediate the ends of said element, said ampule
having three disks in spaced relation therein, two
' of said spaced disks being positioned at one end -’
syringe plunger having a piercing element at one
15 end and said element having a channel positioned
lengthwise thereof, one end of said channel ‘be
ing open laterally of said piercing element and
the other end of said channel being open at one
end of said piercing'element, said element hav
ing one piercing end, said ampule having three
disks in spaced relation therein and one of said
disks being positioned inwardly at one end to
form an open space outside the disk at said end,
said open space being substantially ?lled by said
25 inwardly positioned disk during operation 0! said
ampule.
‘ 6. In combination with a multiple compart
ment ampule of the class described, said ampule
having three disks in spaced relation therein, a
hypodermic syringe plunger having a piercing el
ement at one end, two of said spaced disks being
positioned at one end or said ampule to be suc
cessively penetrated by said piercing element,
said element having a channel positioned axially
thereof, said channel having inlet means later
ally and-intermediate the ends of said piercing
element and having an outlet at one end of said
of said ampule to be successively penetrated by
said piercing element, said lateral inlet means 15
being spaced from said collar a distance substan
tially equal to the thickness of the end disk to
be initially penetrated, onev disk being positioned
inwardly at one end of said ampule to form an
open space outside the ‘disk at said ‘end, said 20
open space being substantially ?lled by said in
wardly positioned disk during operation of said
ampule.
_
"
8. A multiple ampule having a plurality of disks
and being adapted for use in a syringe having two
needles for piercing the disks from opposite ends
0! said ampule, comprising tubular outer con?n
ing means and a plurality of spaced separators
frictionally secured in sealing relation in said
con?ning . means to form separated compart
ments hermeticallysealed from each other, all
of said separators being of the same diameter
throughout their length and slidable in said tu
bular con?ning means. throughout its length.
m'rnmw mzms.
CLAYTON H. mm‘.
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