Патент USA US2115731код для вставки
May 3, 1938. M. LOZIER’ETAL‘ ’ ~ v 2,115,731 ' MULTIPLE COMPARTMENT AMPULE AND HYPODERMIC VSYRING‘E Filed Feb. 4, 1957 ‘ NA 7'7'HEW LOZ/E'Ri v > CLAY TON />-/. FROJ 7' ' INVENTORS ATTORNEY Patented ‘May3, 1938 . $2,115,731 UNITED STATE 8‘ PATENTQOFFICEY 2,115,731 MULTIPLE COMPABTMENT .AMPULE AND , ~ _ , HYPODEBMIG SYRINGE , , ~ Matthew Loller, Brooklyn, N. Y.,‘ and Clayton H; Frost,v Union, N. Insulators,‘ byxdirect and _ ‘ meme assignments, to Cook Laboratories, Inc., New York; N. Y.,>a corporation of Delaware Application February 4, 1931, Serial No."124,0l0: ' ' 80mm. (01.1287-215) This invention relates to a- multipl'epcompart drawn.‘ An object of this invention is to provide, a‘ 5 container ‘having separate compartments con taining dissimilar ingredients, the said compart ments‘ being de?ned by spaced stoppers of pierce able material and‘ which are slidably positioned 10 " view- of ‘our double compartment “ampule, com- 5 prising an elongated tubular outer member or casing“ preferablyv made of glass?and having‘ a pluralitylof disk-shaped stoppers I2, I21 and _V v . _ .' tion" the numeral III .‘indicates a cross-sectional. , Another object of this invention is to provide a multiple compartment ampuie which may be inserted into a hypodermic syringe for surgical or dental use. . ‘In the illustrated embodiment oi the_inven ‘ in. the container. r discharged'and shows the piercing element with-l ment ampule and to a hypodermic syringe de signed for use with said ampule. - I!2 inserted. "Thestoppers vare preferably made _ of a' yieldable material such as rubber, and are 10 of suillcientlylarge external‘. diameter to friction allg engage the internal diameter of the tubular member llv in sealing relation. I Another object of this invention is- to'provide 15 a hypodermic syringe having a plunger with a piercing element, the said element having a chan _ v ' Figure vl shows the ampule with the stoppers positioned therein in “spaced relation so was to 15' form two compartmentsv i3, H, which may con- - ' dissimilar liquids ‘and is hermetically "sealed'_ nel designed to provide communication between ' tain the compartments in the said ampule when the from eachother by the disks i21 due to its fric? piercing element is pushed through adjacent’ tional sealing engagement‘ in the, tubular mem ber ii. ‘It will be noted ‘that in Figure l'the 20 20 stoppers. with the ‘above and other objects in view, the disk I! vis positioned ator ‘near one end i5 of invention‘ will be hereinafter more particularly the tubular member ii," andthat'the disk‘ l21_ is spaced at a predetermined distance ‘therefrom to form the compartment 13, whilev the'disk I23 has been positionedinwardly from the end l?f'of 25 25 form part of thisjspeciilcation. Reference will now be had'to the drawing,j the tubular member "so as to form thel'closed" compartment’ i4.;-,'I'his position of ‘the disk i22 wherein like numerals of reference designate cor described in connection ‘with the accompanying drawing and pointed out in the'claims which the end it and‘ the stopper I21 is gov-‘l ~ responding parts throughout the-several views, between emed by the length or; the compartment [3. 'The ‘ in which: 30 ' ' ' ' j Figure 1 is a central longitudinal cross-sec tional view of our multiple compartment ~ampule' having disks in predetermined spaced relation therein, and being designed for surgical or dental use, in conjunction with a hypodermic syringe 36 having a piercing element designed for the pur pose, the ampule being shown on an enlarged scale. ‘ Figure 2 is a cross-sectional view or a frag mentary portion of the ampule with the piercing 40 element inserted in two adjoining disks therein and with the said disks remaining in the posi tion shown in Figure l. ' Figure 3 is a cross-sectional view ‘of the'a'm pule after the liquid in one compartment has 45 been transferred into the other compartment; and shows the piercing element inserted through two adjoining disks in the ampule. ' length of the open end space'is substantially the 80, same as the length of the compartment IS. The end space is essential to permit the movement » of- the‘ disk l2" when the liquid in the compart ment i3 is transferred into the compartment i4. I For" the purpose of our inventiom all the stop- 85 ’ per'smust be positioned entirely inside‘ and fric tionally slidable in the tubular member N. Fig ture I shows the ampule' ill with three stoppers or disks of the same diameter throughout‘ their length positioned‘ before the liquid in the con'i'-' 4° partment i! has been transferred into the come‘ partment l4. ' 1 ' - _ j , Figure 2 'shows a iragmentary portion of an ampule iii having the piercing element 20 of a, hypodermic syringe-plunger inserted in’ the disks ‘5 l2 and I21. _ v " ‘ i " ' Figure 3 shows a cross-sectional view of ' an am pule l0 having the piercing‘ element 20 “inserted, able plunger having the piercing element and in the disks l2 and-I21 ‘and'the said disks vmoved Figure 4‘ shows a fragmentary'portion of a slid 50 forming part of a hypodermic syringe shown in Figure 5. ' Figure 5 is a plan view of a hypodermic syr- Q . inge adapted for use with our multiple com partment ampule, showing all the disks in‘po inwardly Figure 4ofshows the casing a fragmenta' ‘l I‘. 1 portion t of the plunger I'I forming part of the hypodermic sy'ringe i8 shown‘in Figure 5'. It will be'noted that the head I! of the plunger l'l has secured there 66 sition when the- liquid in the ampule has been ' to a hollow‘piercing‘ element 20 having a sharp 55 2 2,116,781 and tapering end portion 2| and an axially po sitioned channel 22 adapted to communicate with an aperture 25 in the side of the element 20. As will be'seen from Figures 1 and 4 the ap erture 25 is positioned from the head or collar I 9 a distance substantially equal to the thick ness of the-enddisk l2. _ _- described and illustrated the preferred embodi ment of our invention, but it will be understood that various changes and modi?cations can be made therein without departing from the scope oi.’ the invention as de?ned by the appended claims. - Due ‘to the""sharpness oi’ the piercings-element and the frictional resistance of‘ the disks l2, I21 10 and I23 in the tubular member Ii, it is possible ‘We-claim: . g . l . 1. In a multiple compartment ampule: oi’ the class described comprising a tubular outer mem her and three spaced disks irictionally secured in to pierce the stoppers or disks l2 and I21 by relation therein to form separated liquid exerting manual pressure against the handle '23 _ sealing compartments hermetically sealed from each of the plunger l1 without altering the position other, said disks being at least partially centrally of the said disks. It is to be notedthat the 15 piercing element 20 may also be ‘utilized-inde- ' intact and being pierceable, all of said disks being pendently oi’ the plunger of the hypodermic syr-' 01' .the same diameter throughout their length and 15 being entirely. inside said tubular member, two " ‘ said'disks being in closely spaced relation at When the compartments Ill and I4 contain ‘ of one end and one oi’ said disks being positioned in liquids, due to the incompressibilityoi the liquids, wardly oi the opposite end to form an open space inge I8. 20 when further pressure is exerted against the plunger I‘! it will cause the disk 12 to be moved into contacting relation with the disk "1' ‘and the disk I22 to move simultaneously and equally to the end II of the ampule Ill, since the channel 26 22 in the‘ piercing element 20 connects the co - partments l3 and I4 and permits transfer of the at said end, the length of said end space being substantiallythesame asrthe distance between said closely spaced disks, said end space being substantially ?lled bysaid inwardly positioned disk by outwardv movement thereof to permit transi'errence of the liquid from the compartment . 25 liquid from the compartment ll into the com-j between said closely spaced disks into the length ened ‘adjacent, compartment .when said, closely Dartment II. It is to be noted that both end disks spaceddisks are successively perforated, both end l2 and I2’ are movable simultaneously and equally disks being movable simultaneously and equally 30 ‘while the ‘intennediate disk I 21 remains ?xedv dur-, while the intermediate disk remains ?xeddurin‘g 30 ing said liquid transferrence. , v ,. Further outer movement 01' the disk I 2:I is pre vented by the front inner end of. the hypodermic syringe la in which the ampule"! may be con ?ned ‘during the trar‘lsi'errlng operation. _ ' Further movement oi’ the plunger I‘! will cause the discharge of the combined liquids from the compartment II when the inner end of a hypo dermic needle 24 passes through the disk I21. As shown in Figure l, the disk I 22 has a cavity 28, to permit the piercing element to enter there inand thus allow the disk I21 to get into substan tially contacting relation withthe disk l22 in the position when the element I‘! has already through the disks I2 and l21~and the ampule has been discharged of its liquids. . ' It is to be noted. that while it is preferable to ‘provide a cavity in the disk III, as above men tioned, it is possible for the ampule to be operable 50 when the disk I22 is without a cavity. Also when the disks l2 and I21 are provided with cavities similar to cavity 26. . rIt is to be noted that when the compartments II and ill contain liquids, thatall three separa tors will move during the‘ discharging operation. However, when one of the ingredientsis in pow der form or semi-solid form only two of the separators will be moved. ‘ . It is also to, be, noted that while we havedis closed separators in solid disk form and also in a form showing a cavity in the disk, that, these separators may ‘take the form of cup washers (not shown). } It is also to be noted that the gist 01’ our inven-_ 65 ; tion is to make it possible to bringsdissimilar ma terials con?ned in separated compartments into said liquid transi'en'ence. . ‘ I 2. A multiple compartment ampule having a plurality of 'disks and being adapted for use in a syringe having two needles for piercing the'disks' from opposite ends of said ampule, comprising a' 35 tubular outer member and three spaced‘ disks frictionally secured in sealing relation therein‘ to form separated / compartments hermetically sealed from each other, two oi'sai‘d" disks being respectively‘ positioned substantially at the ends of said tubular member and one of said disks be ing positioned in spaced .relation' between said end disks, one of said end disksbeing at one end of said tubular member and the other end disk being positioned inwardly'oi- the opposite end to form an open space at said end-said open space being substantially closed by said inwardly po sitioned disk during operation of said ampule. 3. A multiple compartment ampule oi’ the class described. comprising a ‘tubular outer member and three spaced 'disksirictionally secured in sealing relation therein to form separated com partments hermetically sealed from. each other. all of said disks being pierceable and normally imperiorate, all 01' said disksbeing oi’ the same diameter throughout their length and being en tirely inside said tubular member, two of said disks being in closely spaced relation at one end and one of said disks being positionedinwardly oi the opposite end to form an. open space at said end, the length oi’ said end space being substan; tially the same as the distance between. said close-2 ly spaced end disks. said end space being substan tially ?lled by outward movement of said inward, ly positioned disk during said transierrence when said closely spaced disks are successively perfo rated, both end disks being movable simultane ously and equally while the intermediate disk re casing Ii ; it is, however, within the scope of our, mains ?xed during said liquid transferrence. 70 invention to house the dissimilar materials in in 4. A multiple compartment ampule having a dependent casings and to join them into opera plurality of disks and being adapted for use in tive relation (not shown) so as to carry out the a syringe having two needles for piercing the objects oi’ ourinvention which are carried» out in disks from opposite ends of said ampule, compris the embodiment shown. a tubular outer‘ member and a plurality of 76 In accordance with the patent statutes we have ing spaced disks irictionally. secured in‘sealing rela 75 contacting relation. As shown in Figure 1, the separated compartments l2 and I4 are in one 3 9,115,781 element, a collar ?xed to said piercing element, said lateral inlet means being spaced from said collar a distance substantially equal to the thick tlon ‘therein to form separated compartments hermetically sealed from each other, all of said disks being of the same diameter throughout their length and being entirely inside said tubular member, two of said disks being in close relation at one end and one of said disks being positioned inwardly of the opposite end to form an open space outside the disk at said end, said open space being substantially ?lled by said inwardly posi tioned disk during operation of said ampule, and said disk having a cavity in one face thereof. a 5. In combination with a ‘multiple compart ment ampule of the class described, a hypodermic ness of the end disk to be initially penetrated. , 7. In combination with a multiple compart ment ampule ‘of the class described, a piercing element having one piercing end and a collar at the end opposite the piercing end, 'said element having a channel positioned axially thereof, said channel having inlet means laterally and inter 10 mediate the ends of said element, said ampule having three disks in spaced relation therein, two ' of said spaced disks being positioned at one end -’ syringe plunger having a piercing element at one 15 end and said element having a channel positioned lengthwise thereof, one end of said channel ‘be ing open laterally of said piercing element and the other end of said channel being open at one end of said piercing'element, said element hav ing one piercing end, said ampule having three disks in spaced relation therein and one of said disks being positioned inwardly at one end to form an open space outside the disk at said end, said open space being substantially ?lled by said 25 inwardly positioned disk during operation 0! said ampule. ‘ 6. In combination with a multiple compart ment ampule of the class described, said ampule having three disks in spaced relation therein, a hypodermic syringe plunger having a piercing el ement at one end, two of said spaced disks being positioned at one end or said ampule to be suc cessively penetrated by said piercing element, said element having a channel positioned axially thereof, said channel having inlet means later ally and-intermediate the ends of said piercing element and having an outlet at one end of said of said ampule to be successively penetrated by said piercing element, said lateral inlet means 15 being spaced from said collar a distance substan tially equal to the thickness of the end disk to be initially penetrated, onev disk being positioned inwardly at one end of said ampule to form an open space outside the ‘disk at said ‘end, said 20 open space being substantially ?lled by said in wardly positioned disk during operation of said ampule. _ " 8. A multiple ampule having a plurality of disks and being adapted for use in a syringe having two needles for piercing the disks from opposite ends 0! said ampule, comprising tubular outer con?n ing means and a plurality of spaced separators frictionally secured in sealing relation in said con?ning . means to form separated compart ments hermeticallysealed from each other, all of said separators being of the same diameter throughout their length and slidable in said tu bular con?ning means. throughout its length. m'rnmw mzms. CLAYTON H. mm‘.