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Патент USA US3028012

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April 3, 1962
Filed June 50, l958
‘7bal s
A
c. NICOLLE
PACKAGE OF PHARMACEUTICAL COMPOSITION
AND THE LIKE MOLDED IN SITU
3,028,002
2 Sheets-Sheet 1
April 3, 1962
c. NICOLLE
PACKAGE OF PHARMACEUTICAL COMPOSITION
AND THE LIKE MOLDED IN SITU
Filed June 30, 1958
F7 .6’
9
3,028,002
2 Sheets-Sheet 2
5'!
a
a
5,
fig. .9
United States Patent 0 ”
CC
3,028,002
Patented Apr. 3, 1962
1
2
3,028,002
a sealing station so that said. composition ?lls thelvfree
spaces de?ned between said ?rst and second receptacles,
said second receptacles having top vents for discharge of
PACKAGE 0F PHARMACEUTICAL COMPOSITION
AND THE LIKE MOLDED IN SITU
Charles Nicolle, 54 Ave. Foch, Paris, France
Filed June 30, 1958, Ser. No. 745,751
Claims priority, application France July 1, 1957
2 Claims. (Cl. 206-631)
This invention relates to the production of packages of
air from said spaces, and allowing said metered amounts
of composition to set within said spaces to provide the
?nished packages.
The above and further objects, features and advantages
of the invention will appear from the, ensuing description
relating exemplary embodiments of the invention selected
moldable compositions, especially pharmaceutical com 10 for illustrative purposes but not for limitation, with refer
positions, which are molded in situ i.e. within the packing
ence to the accompanying drawings, wherein:
The invention more
FIGURE 1 is sectional view of the body member of a
especially relates to the production of suppositories,
packing mold according to the invention containing the
means in. which they are dispensed.
metered amount of composition ?lling the member to a
It is already known to mold suppositories and the like 15 predetermined height;
FIGURE 2 is a view similar to FIGURE 1, after inser
directly within the packing means in which they are even
tion thereinto of a sleeve member according to the in
tually delivered to the market, by pouring metered
though it is by no means restricted thereto.
amounts of the ?uid or semi-?uid composition into re—
vention;
FIGURE 3 is a partial view showing a modi?cation
ceptacles having the desired inner con?guration of the
?nal suppositories, whereby such receptacles serve both 20 of FIGURE 2 on an enlarged scale;
as the molding and the packing means for the ?nished
articles. However, such procedure as heretofore used
has a number of drawbacks which it is a general object
of the present invention to overcome.
FIGURE 4 is similar to FIGURE 2 but relates to
another modi?cation;
FIGURE 5 is a highly simpli?ed view of apparatus
rfor performing the molding and sealing process of the in~
Heretofore the means serving both as the molds and 25 vention according to one form thereof;
FIGURE 6 is similar to FIGURE _2 but relates to
the packing means for such articles were sometimes pro—
another modi?cation wherein the composition is intro
vided in the form of a single unitary receptacle having a
duced into the body member of the packing mold’ in the
top opening through which the ?uid composition was
form of a cylindrical slug or paste-like consistency;
poured, and a ?at strip sealing this opening. Such a
FIGURE 7 is a highly schematic view of apparatus
form of packing means was satisfactory where the molded 30
article or suppository had a simple ogee-like con?gura
for ?lling the body members of the packing molds in
accordance with the method of FIGURE 6;
tion, i.e. av cylindrical body tapered to a point at one end.
FIGURE 8 is an axial view of another form of packing
However, where the molded article is to have a torpedo
mold according to the invention ?lled with a metered
like con?guration, i.e. having an intermediate diameter
larger than the diameter at either end, as is frequently 35 amount of composition, before the shaping sleeve has
been pushed in;
required, a packing mold of the kind just referred to is
FIGURE 9 is a view similar to FIGURE 6 showing the
unsuitable because the article cannot then be readily
components in their ?nal position after the product has
withdrawn out of the packing. In such cases, three-part
been shaped;
packing molds have had to be used, including a two-part
FIGURE 10 is a sectional view of a modi?ed construc
body section or main receptacle separable either in an 40
tion of the upper or end portion of the shaping sleeve;
axial or a transverse direction, and a flat end cover.v
FIGURE 11 is an overhead plan view of the shaping
This three-part construction has greatly complicated the
sleeve shown in FIGURE 8;
manufacturing process. An object of the invention there
FIGURE 12 is a sectional view of a modi?ed con
fore, is to provide a form of combined molding-and
struction of the body member of the packing mold;
packing means for articles of the type described, which
FIGURE 13 is a sectional view of another form of
will be in two parts for simpli?ed production and yet will
the upper part of the shaping sleeve, being generally
allow of easily extracting the ?nished article from its
similar to FIGURE 8;
packing even in cases where said article is of the torpedo
FIGURE 14 is a plan view of another modi?ed form of
like shape speci?ed above.
Other objects are to provide packages of composition 50 the upper portion; and
FIGURE 15 shows part of ‘a bunch of packing molds
molded in situ, which will be easier and more economical
according to the invention.
to produce in large quantities, will contain more accu
In the illustrated embodiments of the invention to be
rately metered amounts of composition per package, will
described, particular reference will ‘be made to the pack
be more uniformly and perfectly sealed for prolonged,
storage life, and handier to use, as compared to similar 55 ing of suppositories, and more particularly still to the
packing of suppositories of the “torpedo” type as earlier
products of the prior art. Objects of the invention also
de?ned. It should be expressly understood however that
relate to methods of producing such improved packages.
the teachings of the invention are essentially applicable
In accordance with an important aspect of the inven—
to packing means for ‘suppositories of other shape, i.e.
tion, there is provided a package of molded composition
comprising a pair of receptacles each sealed at one end 60 ovoidal, as well as to a wide range of other articles of
moldable and shapable character.
and open at the other, one receptacle ?tted into the other
As shown in FIGURES 1 and 2, the packing mold ac
to de?ne therewith a sealed mold cavity, and a body of
said composition molded in situ within said cavity.
cording to one form of the invention comprises two main
In accordance with another aspect, there is provided
components, a ?rst receptacle or body member 1, and a
a method of preparing ?nished packages of molded com 65 second receptacle or shaping and sealing sleeve member
position comprising, relatively displacing a linear array of
upwardly—open ?rst receptacles successively past overhead
metering and sealing stations, feeding a metered amount
3. The body member 1 comprises a generally cylindrical
part with an ogival bottom end. The inner surface of the
body member 1 or ?rst receptacle is formed with a shoul
of said composition in ?uid or semi-?uid state into each
der 2 de?ned at the root of the ogival portion which is of
?rst receptacle as it is positioned under a metering sta_ 70 greater thickness than the cylindrical portion, thereby
tion, inserting a downwardly-open second receptacle into
each ?lled ?rst receptacle as the latter is positioned under
providing the said shoulder. The shoulder 2 serves to
seat the lower end of the sleeve member 3 as shown in
3,028,002
FIGURE 2. The sleeve member or second receptacle 3
has an outer diameter corresponding to the inner diameter
of the cylindrical part of the ?rst receptacle 1, so as to be
4
it contains the center axes of all the members. Similarly,
the shaping and sealing sleeve members 3 may be con
nected to one another rather than being separate as shown
When inserted home so that its
e.g. in FIGURE 2. In this manner an integral bunch may
lower end is seated against shoulder 2, the inner surface
of the second receptacle or sleeve member 3 at its lower
be provided comprising any desired number of similar
packing molds; and if ‘desired frangible areas, such as
end seated against said shoulder, corresponds exactly to
lines of perforations or the like, may be provided between
a friction fit therein.
the adjacent packing molds to facilitate tearing them off
the inner diameter of the ogival end portion of the ?rst
one by one on demand.
receptacle. The inner diameter of the sleeve 3 then grad
It will be noted in connection with the ?lling process
ually decreases upwards from its said lower end, for 10
shown in FIGURE 5 that owing to the fact that the
example according to the contour shown, in order to de?ne
contents p ?lling the body members 1 only reaches up
an inner free space corresponding exactly in contour to
the outer contour of the molded article to be provided;
herein this shape is that of a “torpedo” -'ke suppository
to a point short of the upper opening of said member,
no trouble is experienced during the successive shifting
having a maximum diameter at the shoulder 2.
15 steps of the frame 7 as described above, due to the pos
sibility that would otherwise be present of the liquid con
Formed solid with the upper end of the shaping sleeve
tents of the body members splashing out as each newly
3 is a ?at sealing wall 4, so that it will be seen that the
shaping member and the sealing member herein constitute
?lled body member is shifted from ?lling station 8 to
an integral unit. A side vent hole 5 is formed at the top
sealing station 9. If the body members were ?lled com
of the sleeve to permit discharge ‘of air entrapped between 20 pletely as is usually the case in the prior art, such splash‘
the upper surface of the contents and the sealing wall 4,
ing would result in loss of substance and non uniform
when the sleeve 3 is ‘forced into the body 1.
?lling as well as soiling the outer surfaces of the packing
The packing mold described is used in the following
and apparatus. However, if desired either for further
way. The product p to be packed, preferably in liquid
preventing such splashing or for any other reason, the
or semi-liquid form, is poured into the body member 1 up 25 frame 7 with the mold members 1 thereon may be pro
to a predetermined level n therein, as shown in FIGURE
vided stationary, and the units 8 and 9 may be provided
1, such level being spaced a substantial distance from the
movable instead.
uppermost end of the body 1. The shaping and sealing
As already mentioned the sleeve member or second
sleeve 3 is then inserted into- the body, whereupon the air
receptacle 3 serves the twofold function of a shaping
escapes through the vent 5 ‘and the liquid level rises up
member, in cooperation with the body member 1, and
to the level 12'. At this time the packing operation is com
a sealing means. This is advantageous both in that it
plete, and it is simply necessary to allow the ?lled packing
reduces the number of separate component elements of
mold to cool down so that its contents will set, without
each packing mold to no more than two, and because
any special precautions.
As shown in FIGURE 3, the open upper end of the
it similarly reduces the number of separate operations in‘
volved in the molding and packing process, to a ?lling
body part 1 may be formed with a bevel as at 6, or with
an equivalent rounded ?ared or funnel-like shape to facili
tate insertion of the sleeve 3.
step and a sealing step. These are characteristic features
of the invention and result in a greatly increased e?iciency
A modi?ed construction is shown in FIGURE 4 where
in the inner surface of the cylindrical part of the body 1
and the outer surface of the sleeve 3 are formed with a
ment described, is the excellent seal obtained, due to the
complementary tapered shape preferably over part of their
vertical extent so that, on insertion of sleeve 3 into body
1, the tapered surface of the sleeve is a tight ?t in the
tapered surface of the body.
In FIGURE 5 one arrangement is schematically illus
trated for ?lling the packing molds of the invention where
by the articles are simultaneously shaped and the pack
ing molds sealed. As shown, a set of ?rst receptacles 1
of the packing molds e.g. according to the form shown in
FIGURE 1, are disposed in a movable frame 7 positioned
under a metering feeder 8 of conventional type operable,
when an empty ?rst receptacle is positioned below it, for
and economy of the molding and packing operations.
An additional advantage achieved through the arrange
integral character of the top ?ange 4 with the sleeve 3, in
contrast with what is had with separate sealing strips as
generally used with conventional packing molds of this
kind, wherein the bonding of the strip is apt to be non
45 uniform and portions of the liquid contents are apt to be
lodged between the mold and the sealing strip, especially
due to the aforementioned splashing effect, thereby inter
fering with proper bonding of the strip.
FIGURE 6 illustrates yet another embodiment wherein
the substance p rather than being poured in liquid form
into the body member 1, is introduced in the form of a
cylindrical slug of paste or pulp. The subsequent in
sertion of the shaping and sealing sleeve 3 into the body
introducing a metered dose of fluid or semi-?uid substance
under
suitable pressure, deforms the semi-solid slug and
into the ?rst receptacle 1 up to the prescribed level n 55
forces it to its ?nal shape as determined by the body
therein. The frame 7 is then shifted in the direction
member 1 and sleeve member '3.
indicated by the arrow, to bring the ?lled ?rst receptacle
A suitable ?lling or packing arrangement for use
to a position underlying 1a device 9 serving to insert the
with this form of the invention is shown in FIGURE 7.
second receptacles 3 into the ?rst receptacles 1 over the
_ contents thereof. At the same time, the leftward shifting 60 As shown, a frame 7 is arranged to carry a set of ?rst
receptacles 1 of the kind shown in FIGURE 1 or FIG
of the frame 7 has brought the next following ?rst re
ceptacle 1 on the frame to a point underlying metering
feeder 8 so that it can be ?lled simultaneously with the
URE 6, and it is here assumed by way of example that
all these members are interconnected together by connect
ing ?anges 8, though the members 1 could obviously be
insertion of the second receptacle into the previously
?lled ?rst receptacle by the device 9. This procedure 65 separate as shown in FIGURE 5. Overlying the frame
is a feeding unit 9 which may comprise any suitable ex
can be repeated any desired number of times.
truding means, and delivers a predetermined number of
While the body members 1 of the individual packing
molds have so far been described and illustrated as ele
ments separate vfrom one another, this is by no means es
cylindrical sausage-like elements 10 respectively overlying
a corresponding number of the members 1. Suitable
sential and in fact the invention particularly contemplates 70 means such as a wire 11 are provided for cutting off
predetermined lengths of the elements '10 which then drop
that embodiment wherein all the ?rst receptacles 1 are
into the underlying members 1. The frame 7 is then
integrally interconnected. The interconnections may take
shifted a suitable distance leftward as shown by the
the form of connecting flanges at the upper ends of the
arrow so that the newly ?lled body members 1 are moved
body members 1 or connecting strips extending between
the adjacent body members in a common plane such that 75 to a position underlying a sealing device (not shown)
3,028,002
5
6
To permit discharge of the air entrapped at b (FIGURE
8) on insertion of the sleeve 3, a minute hole 5' may be
for applying the sleeve members 3 as previously described.
The insertion of the sleeves 3 is effected at suitable tem
perature depending on the nature of the contents‘, to be
provided in the end wall a, small enough so that the air
will only be able- to pass through it under the effect of
pressure, speci?cally the air pressure developed in b on
insertion of the sleeve 3 into the body. After the air
has been discharged from b and both components 1 and
packed so as to impart to the slug of material p the neces~
sary plasticity.
It will be understood that, while FIGURE 5 shows a
metering and feeding device 8 and a sealing device 9
each of which cooperates with only a single member 1
3 are properly positioned with respect to each other, the
ori?ce 5’ is in effect sealed, and as impenetrable to out
at a time, and while FIGURE 7 illustrates a feeding de
vice 9 oooperating with a plurality of members 1 at a 10 side air. Even should the suppository or other contents
of the packing mold‘ happen to melt at any time, it will
time and whereas the sealing device (not shown) referred
not be able to ?ow out through the ori?ce 5’ in view of
to in connection with this ?gure was also said to coop
its extremely small area.
erate with the same plurality of members simultaneously,
Instead of the pinprick ori?ce 5' the aforementioned
such arrangements are by no means essential; thus in
FIGURE 5 each of the devices 8 and 9 could be of a mul 15 vent may be provided in the form of one or more slot
like incisions 5". There may be a single cut, as in FIG
tiple or manifold character as the device 9 in FIGURE 7,
URE 10, or there may be two crossed cuts as in FIGURE
while in FIGURE 7 the device 9 might be arranged to
11 or a greater number forming a star pattern as in
extrude only a single sliver of pasty material.
FIGURE 14. On- insertion of the sleeve 3 into body 1 the
In the embodiment of the invention shown in FIG
URES 8 and 9, the second receptacle or shaping sleeve 20 air pressure built up in the space b will force the sides of
the cut 5" upwards and apart to allow said air to escape.
3 instead of being thick-walled as so far shown, is made
On completion of the ?lling operation the pressure is re
from thin ?exible sheet material, such as polyethylene or
moved or replaced by a vacuum so that the sides of the
cut or cuts will close in again to provide a tightly sealed
the like, so that its outer contour is reduced as well as its
inner contour, rather than being generally cylindrical.
This embodiment achieves an economy in packing mate
rial, and has another advantage in that it facilitates ex-1
nur
pulsion of the contents, e.g. suppository, by ?nger pres
sure out of the member 3.
25
assembly.
As shown in FIGURES 8, 9 and 12, the body member
1 may desirably be reduced to minimum vertical dimen
sion thereby saving packing material. Such dimension
should, however, be large enough to contain the full
The body member 1 is preferably made of a relatively
amount of material which is to be contained in the ?nal
hard plastic such as polystyrene or the like, which is 30 packing assembly comprising both members 1 and 3. Re
inexpensive, though it should be understood that it may
ducing the vertical dimension of the body member 1,
also if desired be made of ?exible sheet material similar
moreover, has the further advantage of providing a read
to the sleeve member 3. Another advantage of using a
ily grippable portion of sleeve member 3 projecting above
relatively hard plastic material for making the body mem
the body member 1, to expel the suppository out of the
ber 1 is to facilitate the insertion of the sleeve 3 into
packing in case of a tendency of the suppository to stick
it without tending to deform the body member 1. In
to the body member 1. As already noted, expulsion
fact the combination of a relatively stiff body member
out of the sleeve member 3 is easily elfected by ?nger
1 (e.g. of polystyrene) with a relatively ?exible sleeve
pressure'
member 3 (e.g. of polyethylene) provides an especially 40
To facilitate opening the package in spite of the rela
desirable combination in that it permits of inserting the
tively tight clamping pressure between the two receptacles,
sleeve members with the exertion of only very slight
means such as an annular bead 16 (FIGURE 13) or a
pressure. The requisite seal may be assured by imparting
pair of radial lugs 17 (FIGURE 14) may be provided on
to the sleeve 3 at its lower end an outer diameter slightly
the upper end of slaeeve 3. Instead of projecting in the
larger than the maximum inner diameter of the body 45 plane of said wall as do the lugs 17 in FIGURE 14, such
member. As already described with reference to an—
lugs may be formed to project at an angle, e.g. vertically
other embodiment, insertion of the lower end of sleeve
upward, therefrom; such an arrangement will at the same
3 into body 1 may be further facilitated by imparting to
time further facilitate expulsion of the contents out of the
the upper end of the body 1 a slightly outwardly ?ared
sleeve 3 by ?nger pressure on the lugs.
shape, as shown at e in FIGURE 12, or rounded as 50
As explained in connection with the embodiments ?rst
shown in FIGURES 8 and 9. These latter ?gures also
described, packing molds of the kind shown in FIGURES
illustrate an annular bead r surrounding the upper end
of body member 11 which serves to impart increased
rigidity to the body member as well as facilitating the
8 to 14 may be interconnected into bunches, as shown
in FIGURE 15, which shows a fragment of such a bunch
including two individual packing molds. In the exem
?lling and sealing operations. It will be understood that 55 plary form shown in FIGURE 15 the individual packing
various other modi?cations of shape may be applied to
molds are interconnected by strips 12 extending in a com
mon plane extending through the center axes of all the
the upper end of the body member 1.
packing molds, each strip portion being formed with a
Preferably, as shown in FIGURES 8 and 9, the sealed
weak or frangible area 12 to facilitate separation. FIG
upper end wall a of the sleeve member 3 is slightly domed,
and is very thin so as to yield readily and deform up 60 URE 15 also shows the sleeve members 3 interconnected
‘by top strips or ?anges 14 extending between and gen
wards under light ?nger pressure. This facilitates ex
erally coplanar with the top walls of the sleeves and also
pulsion of the suppository in case it tends to stick to the
formed with weak sections 15 aligned with the sections 13.
walls of the sleeve 3.
It will be understood that various features shown and
Alternatively to the domed shape just described the
upper ‘wall a may be trapezoidal in cross section, i.e. in 65 described with reference to different embodiments may
be interchanged between such embodiments, and numer
the shape of a cone frustum, as shown at a’ in FIGURE
ous other modi?cations made without departing from
10. Both the vertical depth dimension of the domed
the scope and spirit of the invention.
wall a and that of the frustoconical wall a’ may be quite
What I claim is:
small, and in fact said wall can suitably be made flat in
1. A packaging and molding unit comprising a main
those cases where the wall is made from highly ?exible 70
sheet material of suf?ciently high resiliency, such as poly
ethylene, and su?iciently low thickness, and even concave,
body of stiff polystyrene being opened at one end and
having an interior surface which de?nes a cylinder at
said open end and a tapered closed end opposed thereto;
an inner sleeve of ?exible polyethylene having an interior
deform said end wall to expel the suppository or the
surface and telescoped to a predetermined depth substan
75
like from the sleeve.
since pressure exerted on the sides of the sleeve will then
3,028,002
8
tially within the cylinder of said main body, said sleeve
closed only at the end opposed to said tapered closed end
maximum internal diameter of said main body whereby
said sealing of said main body by said sleeve is tight; and
of said main body to thus seal said main body, the in
terior surface of said inner sleeve being shaped to de?ne
in cooperation with said tapered end a mold cavity hav
a product such as a suppository molded to ?ll said cavity
and removable therefrom in said molded shape on open
ing an intermediate diameter larger than the diameter at
least as great as the volume of said product.
either end; and a product such as a suppository molded to
?ll said cavity and removable therefrom in said molded
ing said unit, the volume of said main body being at
References Cited in the ?le of this patent
UNITED STATES PATENTS
shape on opening said unit, the volume of said main body
being at least as great as the volume of said product.
10
2. A packaging and molding unit comprising a main
body being opened at one end and having an interior
surface which de?nes a cylinder at said open end and a
tapered closed end opposed thereto; an inner sleeve hav
ing an interior surface and telescoped to a predetermined 15
1,564,310
2,203,421
2,219,181
Jones _______________ __ Dec. 8, 1925
Stevenson _____________ __ June 4, 1940
Graham ____________ __ Oct. 22, 1940
2,612,261
Percopo _____________ .__ Sept. 30, 1952
2,797,805
Berard ______________ __ July 2, 1957
55,629
France _______________ __ May 21, 1952
493,134
734,838
Belgium _____________ __ May 2, 1950
Great Britain _________ __ Aug. 10, 1955
1,081,229
1,096.474
France ______________ __ June 9, 1954
France ______________ __ Feb. 2, 1955
FOREIGN PATENTS
depth substantially within the cylinder of said main body,
said sleeve closed only at the end opposed to said main
body, the interior surface of said inner sleeve being
shaped to de?ne in cooperation with said tapered end a
mold cavity having an intermediate diameter larger than 20
the diameter at either end, the diameter of said inner
sleeve at its open end being slightly greater than the
(2nd add. Pat. 848,960)
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