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Патент USA US3032188

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May 1, 1962
Filed April 18, 1960
. 3
ALLA/vs. Bucova
Patented May 1, 1962
In fact, some of the disc members will fall separately
from others or in such small groups that it will become
possible for the disc members to turn to an angular posi
tion within the vial and to settle in such angular position
whereby such angular disc members would be incapable
of assuming a proper position for dispensing. The disc
Nicholas J. Menolasino, 1313 N. 14th Ave, Melrose Park,
Ill, and Allan S. Belcove, 6156 N. Hamilton Ava, Chi
cago, Ill., assignors of one-fourth to Seymour gantow
and one-fourth to Dominic Menolasino
Filed Apr. 18, 196i), Ser. No. 23,1l64
members are subjected to such movements one or more
times in their use, as when the vial is inverted after in
sertion into position of use in the disc dispenser or when
This invention relates to the dispensing of discs of light 10 removed and re-inserted as in the substitution of one vial
having one disc member for a vial having another type
weight absorbent material impregnated or otherwise
of disc member.
treated with an anti-biotic or chemical which may be
It is an object of this invention to produce a vial ?lled
used in the treatment of diseases and relates in particular
with a stack of disc members wherein the foregoing dif?
to a package in which such disc members are stacked for
15 culties can be eliminated.
dispensing one at a time in test procedures.
More speci?cally, it is an object of this invention to
Brie?y described, a very important tool has been given
produce a vial embodying a stack of such treated disc
to the medical profession for use as a laboratory test to
members and including means for displacement of the
determine what drugs will probably be effective in com
disc members, as a group, to their lowermost positions
bating certain diseases when given to the patient. For
in the vial properly to position the lowermost disc mem
this purpose, use is made of a plurality of disc members
ber for dispensing and which also embodies means limit—
of absorbent material treated with various anti-biotics or
ing the freedom of movement of the disc members in
chemicals or drugs known to destroy or inhibit the growth
the vial thereby to prevent the free fall of the disc mem
of bacteria and other microorganisms. A culture is pre
bers which might otherwise permit improper alignment
pared in a Petrie or the like dish and various of the
in the stack.
treated discs are positioned in spaced apart relation on
These and other objects and advantages of this inven
the surface thereof and maintained under conditions to
tion will hereinafter appear and for purposes of illustra
encourage continued growth. If the anti-biotic or chemi
tion, but not of limitation, an embodiment of the inven
cal of a particular disc is effective to destroy or inhibit
tion is shown in the accompanying drawing in which:
the growth of the bacteria or other organism, the area
FIG. 1 is ‘a perspective elevational view of a com
in the immediate vicinity of the disc will be free of such 30
pleted package embodying the features of this invention;
growth. Thus an effective drug can be selected for
8 Claims. (Cl. 206-56)
treatment of the particular disease.
Similarly, by the
concentration of the drug impregnated into the disc, the
laboratory can determine if the organism is very sensi
tive, moderately sensitive or resistive to the drug by the
presence or absence of the zone of inhibition.
Ordinarily it is desirable to make use of a plurality of
FIG. 2 is a perspective elevational view of the pack
age of FIG. 1 showing the arrangement of the parts
when in the inverted position;
FIG. ,3 is a sectional elevational view through the vial
of FIGS. 1 and 2 showing the arrangement of parts when
in position of use;
FIG. 4 is a sectional elevational view of the vial shown
in FIG. 3 with the vial inverted to an upright position;
apart relation on the culture. For this purpose, use is
FIG. 5 is a sectional elevational view similar to that
made of a disc dispenser of the type described in the co 40
discs deposited in a predetermined pattern, in spaced
pending application Serial No. 728,415, ?led April 14,
1958, wherein use is made of a plurality of vials mounted
in a suitable stand with the open ends extending down
of FIG. 4 illustrating the misalignment of elements which
is possible in a structure which does not embody the
practice of this invention;
wardly into communication with separate openings in 45 FIG. 6 is a perspective elevational view of a holder
member of the type illustrated in FIGS. 1-4; and
registry with slides by which the lowermost discs in each
FIG. 7 is a sectional view taken along the line 7-7
of the stacks is displaced to aligned openings in the bot
of FIG. 1.
tom side of the dispenser for delivery of the discs to the
In accordance with the practice of this invention, the
underlying culture.
It is desirable for displacement of a disc from each of 50 treated discs 10 formed of a lightweight, pliable cellulosic
material or other absorbent paper, are stacked one upon
the other ?atwise to form a column within a glass vial
12 ?tted with a stopper 14 to conceal the open end of the
vial when not in use. The disc members 10 are shaped
then the lowermost disc will not be in a proper position
to be displaced by the feed slide such that the corre 55 to correspond to the shape of the vial and they are dimene
sioned to be slightly less than the wall to wall dimension
sponding disc member will not be delivered to the posi
of the vial. Thus the disc members are capable of dis
tion of test. Under such circumstances, the de?ciency
placement endwise in the vial alone or incombination in
or de?ciencies must be made up by manual delivery with
the stack. In the illustrated embodiment, the disc mem
the chance of error in placement or in proper selection
bers are circular in cross sections to be received in sliding
of the missing disc or disc members.
60 relation within the bore 16 of a cylindrical‘vial 12.
There are a number of reasons for improper align
To effect displacement of the stack of disc members
ment of the disc members in the vial. One such reason
toward the open end of the vial, when in the lowered
may stem from the lack of su?icient weight for displac
the vials for simultaneous delivery of the disc members
in their separated relation. In the event that the disc
members are in other than a ?atwise position in the vials,
position shown in FIG. 3, there is provided a weight 2%}
ing the stack through the vial so that the lowermost disc
member will be in proper position to be displaced from 65 in the end portion of the vial between the stack of disc
members and the base 22 of the vial. The weight 20
the vial in response to movement of the feed slide.
is dimensioned to have a cross section less than the wall
Another reason for such possible improper alignment
may stem from the various movements of the vial in use.
For example, when the vial is partially ?lled with disc
to wall dimension of the vial and to correspond to the
shape thereof to enable displacement actually in the vial,
members, movement of the vial from inverted to upright 70 in the manner of a piston. Thus, when the vial is in up
right position, as illustrated in FIGS. 1 and 4, the weight
position or vice versa will enable the disc members to
29 will be displaced automatically by gravitational force
shift from one end to the other in the vial. During such
to a position of rest in the base of the vial. On the other
movement, the disc members need not move as a group.
hand, when the vial is inverted into position of use with
the vials for the packaging of disc members for distribu
the open end extending downwardly, as in FIGS. 2 and 3,
the weight shifts by gravitational force to come to rest
on the upper end portion of the stack of disc members
where it can operate constantly to urge the stack toward
tion and use. It will be understood that changes may be
made in the details of the construction of the various
the lowermost position. Movements of the vial, while in
the inverted position, will enable the weight 20 addition
elements are formed, without departing from the spirit
of the invention, especially as de?ned in the following
ally to operate as a ram to cause displacement of the stack
elements including the spring holder and the weight, as.
well as the shape and the materials of which the various
to the lowermost position and constantly to press the stack
toward such position.
We claim:
Thus, the weight functions to
1. A package having a plurality of thin disc members
maintain the stack in its lowermost position in the vial
and to hold the disc members in their ?attened position in
the stack with the lowermost disc member in position to
be engaged by the feed slide for displacement.
To hold the stack of disc members against free and 15
of light weight and adapted to be used with a dispenser
for the displacement of single discs from the package
comprising a vial having a bore extending uniformly con
tinuously therethrough from an open end at the top to
uncontrolled movement as an incident to the movement of
bers of light weight slidably received within the bore of
the vial between inverted and upright position, thereby to
said vial in stacked relation one on the other in the vial
a closed end at the bottom, a plurality of thin disc mem
avoid misalignment of the disc members as illustrated
to form a column dimensioned to be less than the length
in FIG. 5, there is interposed between the weight Ztl and
of the bore, a spring holder inter?tted within said bore
the stack of disc members 10 a holding member 24 which 20 contacting the bottom end of said column remote from
resiliently engages the side walls of the vial with a force
said open end and resiliently engaging the adjacent walls
su?icient to resist displacement to response to the weight
of the vial with a force su?icient to resist displacement
of the stack of disc members but with a force insumcient
by the weight of the stack of disc members, a weight
to resist displacement lengthwise through the vial in re
slidablyreceived in the vial between said spring member
sponse to impacts or force derived from the weight 243. 25 and the bottom of the vial, the resilient engagement by
Thus the resilient holding member 24 serves as a movable
said spring holder being insuf?cient to resist displacement
bottom wall for support of the stack of disc members
by the slidable weight wherr turned bottom side up
to eliminate the formation of a free space through which
whereby the resilient holder operates to form the bottom
the disc members may fall when the vial is returned
support for the stack of disc members in the vial to seal
from inverted to upright position. As a result, once 30 the elements therein.
the stack of disc members has been displaced by the gravi
2. A package as claimed in claim 1 in which the vial
tational force, assisted by the weight, to their lowermost
is of cylindrical shape and in which the weight consti
position, the resilient holding member 24 will also be
tutes a cylindrical member having a diameter less than
displaced into contact with the top side of the inverted
the diameter of the bore extending through the vial.
stack to function as the bottom wall upon which the stack
3. A package as claimed in claim 1 in which the spring
will rest when subsequently shifted to upright position.
holder comprises a strip of spring metal having opposite
side portions extending outwardly for a distance greater
As disc members are displaced from the stack, the re
silient holding member will be displaced by a similar
amount constantly to engage the top side of the inverted
stack and thereby to eliminate free falling space.
For this purpose, the resilient holding member 24 may
be formed of a strip of spring metal bent to U shape with
than the diameter of the bore whereby the said sides are
resiliently displaced in the direction towards each other
when in the vial thereby resiliently to engage the opposite
side walls of the vial.
4. A package as claimed in claim 1 in which the spring
the base 26, extending crosswide in the vial, being dimen
holder comprises a strip of spring metal shaped to have
sioned to be less than the corresponding cross section of
a planar body portion and free arms extending angularly
the bore through the vialand with the side arms 28 ex 45 outwardly therefrom to a distance greater than the bore
tending outwardly angularly therefrom with the span
through the vial whereby said arms are flexed in the
between the outermost portions thereof being greater than
direction towards each other resiliently to engage the side
the corresponding wall to wall dimension of the vial so
walls of the vial when inserted.
that such outwardly extending portions will have to be
5. A package as claimed in claim 4 in which the end
?exed inwardly in the direction towards each other upon 50 portions of the arms of the spring holder are formed to
insertion into the vial resiliently to bear against the walls
curvilinear shape substantially to correspond with the
of the vial. It is preferred to form the arms with end
curvature of the vial for more substantial engagement
portions bent to a curvilinear shape to correspond more
with the curvature of the walls of the vial for more
6. A package as claimed in claim 4 in which the body
substantial engagement therewith but such curvature is 55 portion of the spring holder extends crosswise of the vial
not essential for operation.
to provide a supporting surface for the disc members.
Instead of forming the holding member 24 of trape
7. A package as claimed in claim 4 in which the spring
zoidal shape, the spring holder may be of other shapes
such as V-shape, Z-shape, rectangular shape, curvilinear
holder is of V-shape.
8. A package as claimed in claim 4 in which the spring
holder is of U-shape.
shape and the like. as long as portions thereof resiliently
engage opposite walls of the vial slidably to position the
spring holding member in position when inserted into
References Cited in the ?le of this patent
the vial with a force su?icient to resist easy displacement
by the stack of disc members in the vial.
By the practice of this invention it is possible constantly
to maintain the disc members in proper position for dis—
pensing without excessive waste in the space available in
Hanna ______________ __ May 29, 1928
Schwartz ___________ __ Sept. 12, 1939
Johnston ____________ __ June 22, 1948
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