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Патент USA US3074413

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Jan. 22, 1963
\ “3,074,403
Filed May 17, 1960
Alia/Alf )’.
United States Patent O??ce
Patented Jan. 22, 1963
purposes wherein intracutaneous injection of a biological
is desired.
Illustrative modi?cations of the present invention are
shown in the accompanying drawings in which:
Murray Sam Cooper, Dumont, N.J., Arthur Sinclair 5
FIGURE 1 is a plan view of the injector as cut out from
Taylor, Spring Valley, N.Y., and Virgil Alan Place,
sheet metal stock.
Saddle River, N.J., assignors to American Cyanamid
Company, New York, N.Y., a corporation of Maine
Filed May 17, 1960, Ser. No. 29,627
3 Claims. (Cl. 128-253)
This invention relates to an intracutaneous injector for
FIGURE 2 is a top view after the prongs are bent to
FIGURE 3 is ‘a pictorial showing the device ready for
FIGURE 4 is a modi?cation using a triangular con
the administration of biologically-active preparations
having dual points, which are closely adjacent, and having
gaps between them which, by capillary action, serves to
Certain biological agents, which are either living or
ganisms or derived from living organisms, are used in
either a substantially dry or liquid form for the diagnosis,
prevention or treatment of diseases. Certain of these, in
cluding viral and bacterial vaccines, viral and bacterial
veniently 0.006-inch to 0.010-inch thick. .Thinner stock
may be used, but the prongs are easily bent. Thicker
stock may be used, but the cost is higher, the Wounds are
The injector is conveniently formed from noncorrosive
metal stock, such as stainless steel or a nickel alloy or
retain liquids and therefore give more effective treatment. 15 aluminum. For stainless steel, the sheets are con
larger, and forming is somewhat more expensive. Larger
antigens, antibacterial and antitoxic antiserums, pollen
extracts, and protein extracts, have been administered
devices, of course, would be desirable for the administra
tion of biologics to animals which have a tough skin.
The injector itself, as shown in FIGURE 1, is cut from
through the skin by scari?cation, subcutaneous injection
sheet stock as a forming blank 11 which consists of a
square plate 12, having a cut-out hole 13, and a plurality
and intradermal injection.
For the rapid treatment of large numbers of subjects, 25 of points 14. The hole serves a dual purpose of conserv
ing material and permitting the circulation of liquid
there is a demand for an intracutaneous injector which is
around the injector when used with liquid biologics. The
so inexpensive that it can be used but once and discarded,
prongs 16 are cut externally to the square plate with two
and which gives quick and accurate dosage employing the
prongs adjacent each corner. Conveniently, these prongs
biologics in either dry or liquid form. Among the present
are triangular, one side being an extension of the side of
methods of treatment, as for example in vaccination for
the square with an angular cut back to the adjacent side
smallpox, a drop of the desired biologically-active mate
of the square so that, in effect, a right angle triangle is
rial is placed on the cleansed skin of the subject, and a
formed, one side of which is integral with the square,
along a bend line 15. Preferably, the apex of the prong
and into the skin carrying with it the vaccine. Such a
method of administration is comparatively slow and re 35 has an angle of from about 5° to 45°, an angle of from
10° to 25° usually gives preferred results. Two prongs
quires skill in the use of the needle.
16 adjacent each corner are then bent at right angles to
Various multiple-point devices have been developed to
the square plate and into juxtaposition with each other.
give a multiplicity of abrasions or small cuts in a single
There is a narrow gap 17 between these adjacent prongs.
operation. Some of these have no method of depth con
This gap serves to hold a liquid by capillary action. The
trol other than the skill of the user. Others, such as shown
adjacent prongs may touch each other at some points.
in United States Patent No. 2,893,392, A. R. Wagner and
Usually, there is su?icient spring in the metal so that in
M. S. Cooper, Article of Manufacture for Intracutaneous
the forming operation the prongs are bent into contact,
Injections, have a plurality of sharp points or prongs pro
but spring slightly away.
truding from a plate which gives control over the depth
The present device may be formed by a multiple punch
of penetration of the prongs and which is designed to have 45
ing operation in which the center hole is ?rst punched
the biologic carried into the skin of the subject by the
from a strip of metal, then an octagonal cut-out forming
action of the prongs.
the interval between two sets of prongs on adjacent in
It has now been found that by having two prongs closely
adjacent, with a narrow slot or gap between them, the 50 jectors, and then the diagonal side of the ?rst pairs of
prongs and the straight side of the end prongs, then at the
liquid is drawn into the gap by capillary action and re
next step the angle side of the second pairs of prongs may
tained in the gap. The two prongs cut a more uniform
be cut leaving a residual narrow neck of metal to keep the
wound in the skin and, therefore, give a reliable, uniform
injector in the strip, after which a single bending operation
dosage. With biologics which are dried before use, the
biologic may be placed on the twin prongs in liquid form 55 bends all eight prongs and completes the cut-out giving
the ?nal injector. Such die-forming operations are
and then dried. With biologics which are to be used in
known to those in the metal-forming trades.
liquid form, the liquid is retained by capilliary action in
It is preferred that the prongs be from 1 to 10 milli
the gap. It is found that the biologic does not retreat up
meters in length, with prongs of from 2 to 5 millimeters
the prongs towards their base during drying or adminis
being preferred. The square plate may conveniently be
60 from ‘about 14-inch to %-inch square; 5/i6-inch square
Obviously, as a single use device, there is no problem of
gives a convenient size. The gap conveniently has a
contamination of the biologic with an improperly cleaned
width of a few thousandths of an inch.
applicator, and there is no problem of cleaning or han
In FIGURE 4 is shown an embodiment having a tri
dling of the used instruments.
angular plate with a total of six prongs bent into three
Among the biologics which may be ‘administered are
sets of two. Otherwise, the device is essentially the same
Old Tuberculin and smallpox vaccine and diagnostic
as shown in the modi?cation of FIGURES l to 3.
agents for allergens. The above-mentioned patent
In use, the points 14, which preferably lie in the same
(2,893,392) discloses some such biologics which may be
plane, may be dipped in the biologic which adheres to the
needle point is repeatedly pressed through the active liquid
administered with the present device, including tuberculin
points, forming globules 18. If the biologic is to be dried
tests, tetanus sensitivity, diagnosis of histoplasmosis, blas 70 for storage before use, these globules can be dried and
tomycosis, coccidimycosis, cryptococcosis, sporotrichosis,
remain at the points.
allergen sensitivity, smallpox vaccination, and many other
The angular con?guration of the points cuts an angular
wound which apparently gives greater ef?cacy than the
wound caused by single points.
lHaving described certain embodiments thereof as our
invention, we claim:
1. ‘A one-piece intracutaneous injector comprising:' a
substantially ?at square plate of corrosion-resistant metal,
and adjacent to each of the four corners thereof, and in
tegral therewith, a pair ‘of prongs, one side of each prong
being a substantial elongation of one side of the square
generally’ at right angles to an edge of said triangular
3. A one-piece intracutaneousv injector comprising: a
corrosion-resistant metal plate having a flat portion which
is a polygon in shape, and has a maximum of four sides,
and adjacent to each of the corners of the polygon, a pair
of prongs, the prongs of said pair being respectively inte
gral with the sides of the ?at portion meeting at said
corner, each prong of said pairs of prongs being bent at
plate before being bent, said pairs of prongs being bent 10 approximately a right angle to the ?at portion and closely
adjacent to the other prong of the pair, whereby a liquid
at approximately a right angle to said square plate and
'by capillarity when placed on said prongs is drawn into
closely adjacent to each other, whereby a liquid, by capil
the gap between said prongs; each prong being bent along
larity, when placed'on said prongs is drawn intothe gap
between said prongs.
2. A one-piece intracutaneous injector comprising: a
corrosion-resistant metal plate having a ?at portion which
is triangular in shape, and adjacent to each of the three
corners of the triangle, a pair of prongs, the prongs of said
pair being respectively integral with the sides of the ?at
portion meeting at said corner, each prong of saidpairs ‘
of prongs being bent at approximately a right angle to
the triangular vportion ‘and closely adjacent to the other
prong of the pair, whereby'a liquid by capillarity when
placed on said prongs is drawn into the gap between said
prongs; each prong being bent along a side of the triangle
and each prong, when ?attened to the plane of the tri
angularportion forming a prong extending in a direction
a side of the ?at polygon portion and each prong, when
?attened tothe plane of the ?at polygon portion, forming
a prong having an apex angle of from about 10-25° and
extending in a direction generally at right angles to an
edge of said flat polygon portion.
"References Cited in the ?le'of this patent
Brown _____ _-‘--'-;-V---'._-_'Dec. 15, 1868
Rosenthalv__.___r _______ __ Dec. 2,1952
Wagner et a1. __'__>;.._'_,____ July 7, 1959
McConnell et a1.‘ ______ __ May 15, 1962
Great Britain ____ -_>.._..~_'Feb. 11, 71909
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