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Патент USA US3079405

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grates *ate'nt O "cc
Un
,
3,0793%
Patented Feb. 26, 1963
1
2
3,079,393
THIAZOUNE COMPOUNDS
Harry Louis Yale, New Brunswick, and Francis Alexander
Sowinski, Edison, N..l'., assignors to Olin Mathieson
lower alkoxy-lower aIkyDpiperazinyl [c.g. N4-(2-hydrox
yethoxyethyl)piperazinyl]; and (carbodower alkoxy)pi
perazinyl [c.g. N4-(2-carbomethoXy-, carboethoxy-t, or
carbopropoxy) piperazinyl].
Chemical Corporation, New York, N.Y., a corporation
of Virginia
No Drawing. Filed Feb. 20, 1961, Ser. No. 90,238
9 Claims. (Cl. 26t)—268)
The particularly preferred compounds are those where
in R represents chloro, tri?uoromethyl, t-‘outyl, methoxy
or tri?uoromethylmercapto, and B represents dimethyl
amino, diethylamino or hydroxyethylpiperazinyl.
The compounds of Formula I may be produced by
_ This invention relates to thiazocine compounds. More 10
reacting a 1l,12-dihydro-6H-dibenzo['b,f][1,4]thiazocine—
particularly, the invention relates to basically substituted
thiazocines, their acid addition salts, processes for the
12-carbonyl chloride of the formula
(II)
preparation thereof and new intermediates useful in such
0
L01
processes.
The basically substituted thiazocines may be repre 15
sented by the formula
(I)
(ll—A-lower alkylene-(O-lower alkylene) ,,——B
1°
9
one-1!:
11
1
12\
8
20
2
\C Hz-S
with an alkanol or all-(amine having one of the following
formulas
(III) HO-lower alkylene- (O-lower alkylene)n-B
3
~7 \gHeg/ 4
(IV) NHg-lower alkylene-(O-lower alkylene)n~B
25 (V)
In the above formula and in those which follow, the
various terms and symbols all have the same meaning.
lower alkyl
NH-lower alkylene-(O-lower alkylene) r-B
The reaction is effected in the presence of an alkaline
condensing agent, eg an alkali metal hydride such as
The symbol n represents 0 or 1.
The lower alkylene groups in the formula are straight
or branched chain aliphatic hydrocarbon groups such as
sodium hydride, lithium hydride or the like, in an inert
organic solvent, preferably a hydrocarbon solvent such as
methylene, ethylene, propylene, isopropylene, butylene,
benzene, toluene, xylene or the like.
dimethylethylene and the like. The number of atoms
in the —lower alkylene-(O-lower alkylene),,— chain total
Alternatively, a l1,12-dihydro~6H-dibenzo[b,f][1,4]
thiazocine may be reacted with an alkyl chlorocarbonate,
The symbol R represents hydrogen, any of the four 35 e.g., ethyl chlorocarbonate, in benzene or toluene to give
a compound of the Formula VI,
halogens, preferably chlorine or bromine, trihalomethyl
groups such as tri?uoromethyl, straight and branched
chain lower alkoxy groups such as methoxy, ethoxy, pro
8 or less.
poxy, isopropoxy, butoxy and the like, trihalomethylmer
c‘apto, like tri?uoromethylmercapto and lower alkyl 40
groups, such as methyl, ethyl, propyl, isopropyl, butyl, ,
isobutyl, t-butyl, amyl and the like.
The symbol A represents 0, NH or N-lower alkyl._
The symbol B represents a basic saturated nitrogen 45
co'ntaining radical of less than 12 carbon atoms. The
and this in turn is reacted with an alkanol or alkamine as
nitrogen may bear only hydrogen atoms, e.g. an amino , previously de?ned, to give a compound of the Formula I,
group, or the nitrogen may contain two lower alkyl or ' by alkanol exchange or alkaminolysis.
substituted lower alkyl groups to form, for example, a
The 1l,l2-dihydro-6H-dibenzo[b,f] [1,4] thiazocine-12
dialkylamino substituent, such as dimethylamino, diethyl 50 carbonyl
chlorides of Formula II, which are used as start
amino, a di(hydroxyalkyl)amino substituent such as di
ing materials are produced by reacting a 11,12-dihydro
(hydroXyethyDamino or the like. In addition, the nitro
6H-dibenzo[b,f] [1,4] thiazocine with phosgene in an inert
gen atom may form a saturated 5 or 6-membered N-_ ‘I I solvent
like toluene.
heterocyclic radical of less than 12 carbon atoms in which
The compounds of Formula I form acid addition salts
case B represents, for example, piperidyl [i.e., piperidino, 55 by reaction with an equimolar proportion or excess of an
Z-piperidyl, 3-piperidyl and 4-piperidyl]; (lower alkyl)
inorganic or organic acid. Such salts include hydrohalides
piperidyl [c.g. 2-, 3—, or 4-(lower alkyl) piperidyl or 2-,
such as hydrochloride, hydrobromide, hydroiodide and‘
3-, or 4-(N-lower alkyl)piperidyl]; di(lower alkyl)piper
the like, other mineral acid salts such as phosphate, sul-.
idyl [c.g. 2,4-, 2,5-, or 3,5-di(lower alkyl)piperidyl or 2-,
fate, nitrate, etc., organic acid salts, such as oxalate, tar
3-, or 4-(N-lower alkyl)-2, 3-, or 4-(lower alkyl)piperid
60
r'olidyl; di(lower alkyl)pyrrolidyl; (lower alkoxy)-pyr
trate, malate, citrate, camphorsulfonate, benzenesultonate,
toluenesulfonate, salicylate, benzoate, ascorbate, mandel
rolidyl; morpholinyl [i.e. morpholine, 2-morpholinyl and
3 -morpholinyl]; (lower alkyl)morpholinyl; di(lower
spasmodic agents or antihistamines. They may be ad
yl] ; (lower alkoxy)piperidyl; pyrrolidyl; (lower alkyl)pyr
alkyl)morpholinyl; (lower alkoxy)morpholinyl; thiamor
pholinyl; (lower alkyl)thiamorpholinyl; di(lower alkyl)
thiamorpholinyl; (lower palkoxy)thiamorpholinyl;
piper-
ate, and the like.
The compounds of this invention are useful as anti
65 ministered orally or parenterally by incorporating the base
g. .
or a pharmacologically acceptable acid addition salt there-'
of in a suitable carrier to form tablets, capsules, elixirs,
azinyl; (lower alkyl)piperazinyl (e.g. N4-methylpiper ' injectables and the like according to conventional prac
azinyl); di(lower alkyl)piperazinyl; (lower alkoxy)piper
a'zinyl; ‘(hydroxy-lower alkyl)-piperazinyl [e.g. N4-(2 70 > The following examples are illustrative of the inven
hydroxyethyl)piperazinyl]; (lower alkanoyloxyalkyDpi
tion. All temperatures are expressed in degrees centi
perazinyl [c.g. N,4~(2-acetoxyetbyl) piperazinyl; (hydroxy;
grade.
tice.
,
,
‘3,079,393
3
4
11,12-Dihydro-6H~Dibenz0[bj] [1,4] Thiazocine-IZ-Car
EXAMPLE .1
boxylic Acid, Ester With 4-Dimethylaminobmanol
The reaction of 11,12-dihydro-6H-dibenzo[b,f][1,4]
1I,12-Dihydr0-6H-Dibenz0[bj] [1,4] Thz'azocine
thiazocine-lZ-carbonyl chloride, 10.1 g., 5.2 g. of 4-di
To a stirred solution of 57.5 7g. of a,a-'-dibrorno-o
methylaminobutanol and 2.5 vg. of 50% sodium hydride
dispersion in mineral oil, as described in Example 1,
xylene in7175 ml. of dimethylformamide are‘ added v26.5
g. of o-aminobenzenethiol in 100 ml. of glacial ‘acetic
acid. The mixture is heated ‘at 85-90" 'for three hours,
gives 4.2 g. of l1,l2-dihydro-6H-dibenzo[b,f][1,4]thia
zocine-lZ-carboxylic acid, ester with -4-dirnethylamino
cooled, the crystalline ll,l2-dihydro-6H-dibenzo[-b,f]
[1,4]thiaz,ocine hydrobromide ?ltered and stirred into 10 butanol.
100 ml. of 20% aqueous sodium hydroxide and 250 ml.
11,12 - Dihydro-6H-Dibénzo[b,f] [1,4]'Thiaz0cine-12-Car
of ether. The ether solution is separated and concen
boxylic Acid, Ester With 4-Dimethylaminobutanol, Salt
traded to give 18.0 g. of 11,12-dihydro-6H-dibenzo[bi]
With One Mole of Oxalic Acid
L1,4]lthiazocine, M.P. 104-106".
T042 g. of the above base vin 50 ml. of anhydrous.
11 ,12-Dihydr0-6H-Dibenz0 [b,f][1,4] Thiazocin-a-IZ
Ca‘rbonyl Chloride
15 ether is added 1.1 g. of oxalic acid in 10 ml. of ‘acetone.
The resulting precipitate is ?ltered and recrystallized
from absolute ethanol to give 2.7 g. of product, M.P.
To an ice-cooled solution of 17 g. of 11,12-dihydro-6I-I
dibenzo[b,f] [l,4]thiazocine' in 100 ml. of dry toluene is
added slowly a solution of 15 g. of phosgene in 150 ml. 20
of dry toluene. When the reaction is complete, the mix
ture is ?ltered and the ?ltrate concentrated to dryness in
116-117".
EXAMPLE 3
11,I2-Dihydr0-6H-Dibenz0[b,f] [1,4] Thiazocine-IZ-Cap
boxylic Acid, Ester With 2-(1-Piperazin0)Ethan0l
8.7 g. of 11,12-dihydros6H-dibenzo[bi] [1,4]thiazocine
vacuo to give 11,l2-dihydro=6H-dibenzo[b,f][l,4]-thia
12-carbonyl chloride and 3.9 g. of 2-(1-piperazino)ethan
zocinealz2-ca‘rbbnyl chloride, M.P. 138-140“, after re
01 and 5.2 g. of a 50% dispersion of ‘sodium hydride in
crystallization from Skellysolve E.
25 mineral oil are reacted as in Example 1, to obtain 8.0 g.
of product.
11,12-Dihydro-6H-Dibenzo[b,f] [1,4] Thiaz0cine-12-Car~
A mixture of 34.0 g. of piperidine, 24.8 g. of die'thyl
boxylic Acid, Ester With 1,4-Piperazinodiethanol
ene chlorohydrin, 27.6 g. of potassium carbonate, 100 mg.
A solution of 8.0 g. of the above piperazine derivative
of copper powder, 5 g. of sodium iodide and 50 ml. of 30
in 250 ml. of methanol containing 2.8 g. of ethylene oxide
toluene are stirred and re?uxed for 24 hours. The
is heated under re?ux for 2 hours, concentrated in vacuo,
cooled reaction mixture is washed with water, ?ltered, ex
250 ml. of dry benzene are added and the resulting solu
tracted with dilute hydrochloric acid, the hydrochloric
tion again concentrated to dryness. The ‘residual 11,12
acid extract is gradually treated with an excess'of sodium
hydroxide and the liberated base extracted with ether. 35 dihydro '- 6H - dibenzo[b,f] [1,4]thiazocine-l2-carboxy1ic
acid, ester with 1,4-piperazinodiethanol weighs 7.6 g.,
The ether extract is dried over anhydrous magnesium sul
M.P. 97-9“.
fate, concentrated and distilled to give 30.2 g. of 2-(2'~
11,12-Dihydro-6H-Dibenzoljb,f] [1,4] Thiazocine-IZ-Car
piperidiuoethoxy)ethanol, B.P. 93-94“ (0.5 mm).
1 1 ,1 2-Dihydro-6H-Dibenzo[bj] [1,4] Thiamcine-IZ-Carf
boxylic Acid, Ester With 2-’('2-Piperidin0eth0xy)Efhanol
40
boxylic Acid, Ester With 1,4-Piperazin0diethanol, Salt
To 2.4 g. of 50% sodium hydride in mineral oil sus
pended in 50 ml. of dry toluene, are added 8.8 g. of 2-(2
With 2 Moles of Oxalic Acid
4,
To 7.6 g. of the above base in 50 ml. of acetonitrile
are added 3.6 g. of oxalic acid in acetonitrile. ,The solid
which separates is then recrystallized from 80%- ethanol
piperidinoethoxy)ethanol in 25 ml. of toluene followed
to give 4.6 g. of product, M.P. 185-186° (dec..).
by 9.8 g. of ll,l2r—dihydro-6H-dibenzo[b,t][1,4]thiazo 45
cine-12-carbonyl chloride in 75 ml. oi toluene. The mix
ture is re?uxed for 1 hour, ‘cooled, ?ltered and extracted
,
EXAMPLE 4
[I ,4] Thiazac‘ine-lZ-Carboxy’lic Acid, Ester With 3
with 250ml. of dilute hydrochloric acid. The extract is
their made basic with potassium carbonate ‘and extracted
with ether. Concentration of the ether ‘extract 'afford's 50
10.1 g. of ‘a viscous oil, which on tritu'r‘ation in vdiis‘o
Amin'opropanol
By substituting 38.6 g. of 4-'(tri?uoromethy1)-o-amino
benzenethiol for the o-aminobenzenethiol in Example 1,
prap'yi ether, crystalliie‘s. Recrystallization from lig‘roin
there are obtained 23.5 g. of Z-(tri?uorornethyD-l1,12-dii
gives 4.3 .g. of product, M.P. 69-7-1 °.
hydro-6H-dibenzo[b,f] [1,4-1thiazocine.
EXAMPLE '2
_
_ A mixture of 2.795 g. of 2-(tri?uoromethyl).-1-1,12-di
55
hydro-SH-dibenzoIbilE1,4]thiazocine andv2.0 g. of phos
gene in 100 m1. of toluene are heated under re?ux for
two hours and concentrated to half-volume in vacuo.
I ' 4-Dz‘m'ethyiaminobuty'l-2'-Tetrahydropymnyi Ether
A mixture of 19.12 g. of ‘4-‘chlo‘robu'tyl T-tettr'ahydI'O
pyranyl ether, 18.0 g. ‘of anhydrous dimethylamine, and
This cooled solution of Z-(tIi?uorOmethyD-I1,12-dihy
dro-‘6H-dibenzo [bQf] [l,4]thiazocine-l2-carbonyl chloride
25 ml. of toluene is heated at 94° for 24 hours.
After 60 is ‘then added to 0.8 g. of 50% sodium hydride in mineral
cooling, the reaction mixture is ?ltered. The ?ltrate is
oil and 1.5 g. of 3-aminoprop'anol in 50 ml. of toluene
prepared as in Example 1. The mixture is then re?uxed
concentrated and the residue ‘distilled to give 750.0 g. ‘of
4v-'dimethylaminobutyli2"-tetrahydropyi‘anyl ether, B.P.
for 1 hr. and treated as in Example 1 to give 2-(tri?uoro
methyl) - .11,12-dihydro-6H-dibenzo[b,f][1,4]’thiazocine
90-9-24° 5(2 mm.), 121925 114498.
'
4-Dimezhy’lammobumnel'
65 1.2-‘c'arb'o'xylic acid, ester with 3-aminopropanol.
A ‘solution ‘of 48.3 g. of 4-dimethylaminobutyl .2‘-tetra
hy’dr'opyranyl vether in a mixture of 200 m1. v‘ot' 70% ‘ethyl
alcohol and 3-3 ml. ‘of concentrated hydrochloric acid is 70
heated under re?ux ‘for 1 hour, concentrated to ‘dryness,
EXAMPLE '5
azoéiné-lZ-CZzrbO'x‘ylit: Acid, Ester With l-Pi'peridyl
méthan'o'l'. ‘Z-AminO-P-AnisyI Sulfonic Acid, Sodium
Salt
To ‘a solution of 123.2 guts. of m-anisidine in ‘one liter
the residuemade alkaline with 50% aqueous sodium
I of tetrachloroethane are added 128 gms. of chlorosulfonic
hydroxide, and'extr‘acted with ether.‘ The ether is ‘evap
acid and th'e'mixture‘is ‘stirred at 150° for ‘one hour. The
orated and'the residue ‘distilled to give 15.7 g. of product‘,
75 reaction ‘mixture‘is‘co‘oled, the ~solid ?ltered, air dried and
B.P. 75—77° *(10 mm.), 11324 1.4391.
5
3,679,39é
16
dissolved in 1 l. of hot N-sodium hydroxide. The hot
solution is ?ltered andcooled to give 180 gms. of the
propanol, there is obtained 2-methy1-11,12-dihydro-6H
dibenzo[b,f] [1,4]thiazocine-12-carboxylic acid, ester with
Z-methylaminoethanol.
sodium salt.
Z-Amz'no-p-Anisyl-Sulfonyl Chloridé
EXAMPLE 8
To 225.2 gms. of Z-amino p-anisyl sulfonic acid, sodium
salt, and 10 ml. of dimethylformamide are added 250
ml. of thionyl chloride. The mixture is heated at 90°
N-(3-Dimethyldmin0pr0pyl) - 11,12 - Dihydr0-6H-Dibem
z0[b,f] [1,4] Thiazocine-IZ-Carboxamide
-
-
A mixture of 5.8 g. of 11,12-dihydro-6H-dibenzo[b,f]
for 0.5 hr. and concentrated in vacuo. To the residue
are added 100 ml. of dry benzene and the mixture is 10 [1,4] thiazocine-lZ-carbonyl chloride, 150 ml. of dry
xylene, 4.1 g. of 3-dimethylaminopropylamine and 1.0 g.
again concentrated in vacuo. The product is puri?ed by
dissolving the residue in 100 ml. of ether and washing
of the 50% dispersion of sodium hydride in mineral oil
the ether solution with a saturated solution of sodium
was reacted as in Example 1 to give 3.5 g. of N-(3
dimethylaminopropyl)-11,12 - dihydro-6H - dibenzo[b,f]
bicarbonate. After drying and removal of the ether
there are obtaind 177 gms. of Z-amino-p-anisylsulfonyl 15 [1,4]thiazocine-12-carboxamide, M.P. 121-122".
This invention may be variously otherwise embodied
chloride. To 305 ml. of concentrated sulfuric acid and
within the scope of the appended claims.
2 kg. of ?nely cracked ice kept at -—5° to 0° are added
What is claimed is:
180 gms. of Z-amino-p-anisylsulfonyl chloride followed
1. A compound selected from the group consisting of
by 280 gms. of zinc dust, added in small portions. The
reaction mixture is stirred for one hour and heated under 20 bases of the formula
re?ux for 8 hours. After cooling, the mixture is neutral
ized and steam distilled. The distillate is extracted with
0
ether, the extract dried, concentrated and distilled to
l
give 95 gms. of Z-amino-p-anisylthiol.
(J}—-A-l0wer alkylene- (O-lower alkylene) n_B
Z-Methoxy-l 1 -Dihydr0-6H-Dibenz0 [bj] [1,4] Thiazocz'ne
25
By substituting 31 gms. of 2-amino-p-anisylthio1 for
the o-aminobenzene thiol in Example 1, there is obtained
2-methoxy-1l,12 - dihydro - 6H-dibenzo[b,f][1,4]thiaz
ocine.
A solution of 5.14 g. of 2-methoxy-11,12-dihydro-6H
dibenzo[b,f] [1,4]thiazocine, 2.17 g. of ethyl chloro
carbonate and 100 ml. of dry xylene are heated under re
30
\CHr-S
wherein R represents a member of the group consisting
of hydrogen, halogen, trihalomethyl, trihalomethylmer
?ux for 2 hours and then concentrated to one-half volume
in vacuo. To this xylene solution of 2-methoxy-11,12~ 35 capto, lower alkoxy and lower alkyl, A represents a I
dihydro - 6H-dibenzo[b,f] [1,4]thiazocine-12 - carboxylic
member of the group consisting of O, NH and N-lower
acid, ester with ethyl alcohol, is added 5.8 g. of l-piper
alkyl, B represents a member of the group consisting of
idylmethanol and 0.1 g. of sodium methoxide. The mix
amino, di-lower alkylamino, di(hydroxy-lower alkyl
ture is heated so as to distill the ethanol as formed.
amino and basic saturated 5- to 6-membered nitrogen
When no more ethanol distills, the mixture is concen 40 heterocyclic radical of less than 12 carbon atoms selected
trated to dryness and the residue treated as in Example
from the group consisting of piperidyl, (lower alkyl)
1 to give Z-rnethoxy-l1,12-dihydro-6H-dibenzo[b,f][1,4]
thiazocine-lZ-carboxylic acid, ester with l-piperidyl~
piperidyl, di(lower alkyl)piperidyl, (lower alkoxy)piperi
dyl, pyrrolidyl, (lower alkyl)pyrrolidyl, di(lower alkyl)
pyrrolidyl, (lower alkoxy)pyrrolidyl, morpholinyl, (low~
methanol, as an oil. This oil, 2.0 g., in 25 ml. of dry
ether is treated with 0.19 g. of hydrogen chloride in dry
ether to give the crystalline hydrochloride.
45
er alkyl)morpholinyl, di(lower alkyl)morpholinyl, (low
er alkoxy)morpholinyl, thiamorpholinyl, (lower alkyl)
thiamorpholinyl, di(lower alkyl)thiamorpholinyl, (lower
alkoxy)thiamorpholinyl, piperanzinyl, (lower alkyl)pi~
EXAMPLE 6
perazinyl, di(lower alkyl)piperazinyl, (lower alkoxy)
piperazinyl, (hydroxy-lower alkyl)piperazinyl, (lower
alkanoyloxy-lower alkyl)piperazinyl, (hydroxy-lower al
koxy-lower aIkyDpiperazinyl and (carbo-lower alkoxy)
2-Chlor0-11,I2 - Dihydro - 6H - Dibenz0[b,f,] [1,4] Thi
azocine-IZ-Carboxylic Acid, Ester With J-Pyrrolidyl
ethanol
50
By substituting 32.0 g. of 4-chloro-o-aminobenzene~
piperazinyl, and n represents an integer from 0 to 1,
thiol for the 26.5 g. of o-aminobenzenethiol in Example
and pharmaceutically acceptable acid addition salts
1, there is obtained 2-chloro-11,12-dihydro-6H-dibenzo
thereof.
[b,f] [1,4] thiazocine.
By substituting 5.23 g. of 2-chl0ro-l1,12-dihydro-6H 55 2. 12-di (lower alkyl)amino-lower alkyl esters of 11,12~
dihydro-6H-dibenzol[b,f][1,4]thiazoci11e - 12 - carboxylic
dibenzo [b,f] [l,4]thiazocine for the 5.14 g. of 2-methoxy
acid.
11,l2-dihydro-6H-dibenzo[b,f][l,4]thiazocine and 5.8 g.
3. 11,12-dihydro-6H - dibenzo[b,f][1,41thiazocine-12
of l-pyrrolidylethanol for the 5.8 g. of l-piperidylmeth
carboxylic acid, ester with 4-dimethylaminobutanol.
anol in the procedure of Example 5, there is obtained
2-chloro-11,12—dihydro - 6H-dibenzo[b,f] [1,4]thiazocine
60
12-carboxylic acid, ester with l-pyrrolidylethanol.
EXAMPLE 7
Z-Methyl-IIJZ-Dihydro - 6H - Dibenz0[b,f] [1,4] Thiazo
4. 11,12-dihydro-6H - dibenzo[b,f][1,4]thiazocine-12
carboxylic acid, ester with 2-(1-piperazino)ethanol.
5. 11,12-dihydro-6H - dibenzo[b,f][1,4]thiazocine-l2
carboxylic acid, ester with 2~(2-piperidinoethoxy)ethanol.
6. N-(3-dimethylaminopropyl)-11,12 - dihydro-?H-di
cine-1 Z-Carboxylic Acid, Ester With Z-Methylamino 65 enzo[b,f] [1,4] thiazocine-12-carboxamide.
ethanol
7. A compound of the formula
By substituting 28.0 g. of 2-amino-p-toluenethiol for
the o-amino-benzenethiol in the procedure of Example
1, there is obtained 2-methyl~11,12-dihydro-6H-dibenzo 70
[b,f] [1,4]thiazocine.
By the procedure of Example 4, but employing 2.41
g. of 2-methyl-l1,l2-dihydro-6H-dibenzo[b,f] [1,4]thiazo
cine in place of the Z-(tri?uoromethyl)derivative, and
1.5 g. of 2-methylarninoethanol in place of the S-amino 75
l)
(Ill-CI
/
CHz-N
\CH1—S
\
8
7
- 'Revfexences Cited'ivn the ?le of’ this patent
FOREIGN PATENTS
whgkrgig Rdmpresmts' a member of the group consisting
pf hydrbgen, halogen, tribalomethyl; trihalomethylmer
capto, loiver alkoxy and lower alkyLr
8. 11,12-dihydro-6H - dibernzoljbi]{1,41thiazocine-12
carbonyl chloride.
.
5
Z-(gri?upryomethyhl1,12-dihydro46H'- dibenzolbi]
[1,41 thiazocine!IZ-carbonylchlo?de.
.
208,870
537.946
Austria ______________ _.. May 10, 1960
Belgium _____________ __ May’ 31, 1955
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