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Патент USA US3092646

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EXAMlNcn
cross ‘REFERENCE
United States Patent 0 ” "ice
./ .15"O
3,092,636
Patented June 4, 1963
2
1
dibenzyloxy - a - haloalkanophenone and 2 - (1 - alkyl
eneimino)ethylamine. When an acid acceptor is not in
cluded, it is preferred to employ at least 2 moles of 2
3,092,636
a-[Z-(l - ALKYLENEIIVIINO)ETHYLAMINO] - ALKA
NOPHENONES AND THE CORRESPONDING
ALCOHOLS
(1-alkyleneimino)ethylamine per mole of 3,4-dibenzyl
oxy-a~ha1oalkanophenone. The reaction can be carried
out at temperatures ranging from about --25° to about
100° 0., preferably from about 0° to about 75° C. The
Richard V. Heinzelman, Kalamazoo Township, Kalama
zoo County, and Brooke D. Aspergren, Kalamazoo,
Mich., assignors to The Upjohn Company, Kalamazoo,
resulting on - [2 - (l - alkyleneimino)etl1ylamino] - 3,4
Mich., a corporation of Delaware
dibenzyloxyalkanophenone can be recovered in the free
No Drawing. Filed Oct. 21, 1959, Ser. No. 847,682
9 Claims. (Cl. 260—326.5)
10 base form by conventional methods of separation, but it
is preferable to neutralize the reaction mixture with acid
This invention pertains to novel organic compounds,
and more particularly it pertains to a-{l-[2-(l-alkylene
and thus obtain an acid addition salt for use in the sub
imino)ethylamino]alkyl} derivatives of protocatechuyl
sequent reduction and debenzylation.
Reduction and debenzylation of the a-[2-(1-alkylene
alcohol, and to a process for preparing the same.
imino ) ethylamino] -3 ,tdibenzyloxyalkanophenone
The compounds of the invention have, in their free
base form, the following general structural formula:
acid
addition salt to the corresponding acid addition salt of
a - {l - [2 - (1 - alkyleneimino)ethylamino]alkyl}proto
catechuyl alcohol can be accomplished catalytically with
hydrogen in the presence of a noble metal catalyst, e.g.,
(CH3)m
OH R
20
preferably palladium-on-charcoal, platinum-on-charcoal,
and the like. Alternatively, reduction of the carbonyl
group to a secondary alcohol group can be accomplished
electrolytically or chemically (e.g., using sodium and
wherein R is hydrogen or a lower-alkyl radical contain
ing from 1 to 4 carbon atoms, inclusive, for example,
alcohol, or a metallic hydride such as lithium aluminum
represents an integer from 4 to 6, inclusive; and m repre
sents an integer from 0 to 2, inclusive.
of a noble metal catalyst of the kind indicated.
methyl, ethyl, propy, butyl, isobutyl, and the like; n 25 hydride or sodium borohydride) followed by debenzyla
tion by means of catalytic hydrogenolysis in the presence
Illustratively, reduction and debenzylation of a-[Z-(l
alkyleneimino)ethylamino] - 3,4 - dibenzyloxyalkano
protocatechuyl alcohols of the invention (Formula I
above) possess sympathomimetic activity and lack pressor 30 phenone dihydrochloride is accomplished by dissolving in
The novel a-{l-[2-( l-alkyleneimino) ethylamino] alkyl}
activity. The compounds are bronchodilators and can
be administered to mammals for the treatment of bron
chial spasms, e.g., asthma. The compounds also are
a solvent such as water or a lower alkanol, e.g., methanol,
active as uterine relaxants and can be used in the treat
ment of dysmenorrhea and threatened abortion, and in
the prevention of premature labor.
The compounds of this invention can be prepared by
various methods. A general procedure involves halo
alkyleneimino)ethylamino]alkyl}protocatechuyl alcohol
alkanophenone; substituting a 2-(l-alkyleneimino)ethyl
invention (Formula 1, above), 3,4-dihydroxy-a-chloro
ethanol, propanol, and the like, adding catalyst, introduc
ing hydrogen, and agitating the reaction mixture until
hydrogen absorption ceases. The resulting a-{l-[2-(1
dihydrochloride is recovered in conventional manner, such
as by removing the catalyst, evaporating the solvent, and
purifying the product if so desired, e.g., by recrystalliza
tion.
genating 3,4-dihydroxyalkanophenone, preferably after
preliminary benzylation, to give 3,4-dibenzyloxy-u-halo 40 In an alternative preparation of the compounds of the
alkanophenone is prepared by condensing catechol ac
amino group for the halogen; neutralizing the a-[Z-(l
cording to well-known procedures with an a-ChlOI‘O
alkyleneimino)ethylamino] - 3,4 - dibenzyloxyalkano
alkanoyl halide, e.g., chloroacetyl chloride, a-chloropro
ducing and debenzylating the cz—[2-( l-alkyleneimino) 45 pionyl chloride, a-chlorobutyryl chloride, u-chlorovaleryl
chloride, and the like. The 3,4-dihydroxy-a-chloroalkano
ethylamino]-3,4-dibenzyloxyalkanophenone acid addition
phenone thus obtained is then reacted with Z-(l-alkylene
salt thus formed to a-{1-[2-( l-alkyleneimino)ethyl
imino)ethylamine under the conditions outlined above to
amino]alkyl}protocatechuyl alcohol acid addition salt.
phenone free base thus formed with acid; and then re
form a-[2 - (l-alkyleneimino)ethylamino]-3,4~dihydroxy
alkanophenone; an acid-addition salt is prepared, and
Halogenation of a 3,4-dibenzyloxyalkanophenone can
be accomplished by direct halogenation. For example,
3,4-dibenzyloxy-a-haloalkanophenone is obtained by re
acting 3,4-dibenzyloxyalkanophenone with chlorine or
reduction is carried out catalytically, electrolytically, or
chemically as described above, to obtain the desired a-{l
[2 - (1 - alkyleneimino)ethylamino] alkyl}protocatechuyl
bromine. Illustratively, 3,4 - dibenzyloxypropiophenone
or 3,4-dibenzyloxybutyrophenone is dissolved in a suitable
alcohol acid adidtion salt.
Acid addition salts of the a-{l-[2-(l-alkyleneimino)
et-hylamino] alkyl}protocatechuyl alcohols of the inven
tion (Formula I above) are preferably obtained from the
corresponding acid addition salts of the a-[2-(l-alkylene
solvent, for example, methylene chloride, benzene, chlo
roform, dimethylformamide, and the like, and reacted
with bromine in the presence of an acid acceptor such
as the salt of a weak base and weak acid (e.g., calcium
imino)ethylamino] - 3,4-dibenzyloxy (or dihydroxy)alka
carbonate, sodium carbonate, and the like) or a tertiary
amine base (e.g., pyridine, triethylarnine, and the like), 60 nophenones of the invention, according to the process
described above. The acid addition salts of the ot-[Z-(l
to produce 3,4-dibenzyloxy-a-bromopropiophenone and
3,4-dibenzyloxy-u-bromobutyrophenone, respectively.
The substitution of the 2-(l-alkyleneimino)ethylamino
group for the a~halogen of the 3,4—dibenzyloxy~a-halo
alkanophenone is conveniently accomplished by dissolv
alkyleneirnino)ethylamino] - 3,4 - dibenzyloxy (or dihy
65
droxy) alkanophenone intermediates are prepared by re
action with a desired acid, illustratively, a desired phar
macologically acceptable organic or inorganic acid, for
ing the 3,4-dibenzyloxy-a-haloalkanophenone in an inert
example, hydrochloric, hydrobromic, sulfuric, phosphoric,
organic solvent, for example, benzene, toluene, tetrahy
drofuran, ether, ethanol, and the like, and reacting it
tartaric, citric, acetic, butyric, succinic, quinic, and like
acids.
with 2~(1-alkyleneimino)ethylamine. When an acid
When used in pharmaceutical formulations, the novel
70
acceptor, for example, sodium carbonate or potassium
a - {1 - [2 - (1-alkyleneimino)ethylamino]alkyl}protocat
carbonate, is included in the reaction mixture, it is pre
echuyl alcohols of the invention (Formula I above) are
ferred to employ substantially equimolar amounts of 3,4
M
3,092,636
4
ethyl}protocatechuyl alcohol dihydrochloride was re
preferably employed in the form of pharmacologically
covered by ?ltration and was dried under reduced pres
sure at about 25° C. The compound melted at 194° to
acceptable acid addition salts. Thus, a salt can be com
bined with solid or liquid pharmaceutical carriers and
formulated in the form of tablets, powder packets, or
capsules, using starch and like excipients, or dissolved
195° C. and gave the following analysis:
Calculated for C15H26Cl2N2O3: C, 50.99; H, 7.42; N,
7.93; Cl, 20.07. Found: C, 51.01; H, 7.26; N, 8.04; Cl,
or suspended in suitable solvents or vehicles, for oral or
20.04.
parenteral administration.
Further, the a-{l-[2-(l-alkyleneimino)ethylamino]
alkyl}protocatechuyl alcohols and a-[2-(1-alkyleneimino)
EXAMPLE 2
ethylamino] alkanophenones of the invention are useful, 10
in accordance with US. Patents 1,915,334 and 2,075,359,
Preparation of a-{[2-(1-Pyrrolidinyl)Ethylamino]Methyl}
Protocareclzuyl Alcohol Dihydroclzloride
in preparing amine ?uosilicate mothproo?ng agents and,
PART A
in accordance with U.S. Patents 2,425,320 and 2,606,155,
in preparing amine thiocyanate-formaldehyde condensa
Preparation of a-[2-(I-Pyrrolidinyl)Ethylamino]-3,4
15
tion products for use as pickling inhibitors.
Dihydroxyacetophenone Dihydrochloride
The following examples are illustrative of the process
and products of the present invention, but are not to be
A 500 ml. S-necked, round-bottom ?ask was ?tted with
construed as limiting.
a stirrer, dropping funnel, and re?ux condenser. A quan
tity, 11.4 g. (0.1 mole), of 2-(1-pyrrolidinyl)ethylamine
EXAMPLE 1
20 was added, dropwise, to a stirred slurry of 18.6 g. (0.1
Preparation of a-{I-[2-(1-Pyrrolidinyl)Ethylamino]
Ethyl}Protocalechuyl Alcohol Dihydrochloride
PART A
Preparation of a-[2-(I-Pyrrolidinyl)Ethylamino]-3,4
Dibenzyloxypropiophenone Dihydrochloride
mole) of 3,4-dihydroxy-a-chloroacetophenone, 150 ml. of
isopropanol, and 12 g. (0.11 mole) of sodium carbonate.
The reaction mixture was heated under re?ux for 1 hour,
and while still warm was ?ltered with suction. The ?lter
25 cake was washed with 100 ml. of isopropanol. The com
bined ?ltrate and washings were acidi?ed with ethanolic
A 2-liter, 3-necked ?ask was ?tted with a stirrer, re
hydrogen chloride, prepared by dissolving 11 g. of gaseous
?ux condenser, and dropping funnel. A quantity, 212.7
g. (0.5 mole), of 3,4~dibenzyloxy-m-bromopropiophenone
hydrogen chloride in 40 ml. of ethanol cooled in an ice
bath. After cooling the mixture to about 25° C. the re
dissolved in 800 ml. of benzene was introduced and 30
stirred. To the stirred solution was added, dropwise
during an interval of 30 minutes, 114.2 g. (1.0 mole) of
2-(1-pyrrolidinyl)ethylamine. The reaction mixture was
sulting solid a-[Z-(l-PYITOlidiIIYl) ethylamino]-3,4-dihy
droxyacetophenone dihydrochloride was recovered on a
?lter and dried under reduced pressure. The compound
had a melting point of 242° to 244° C. (with decomposi
stirred for 3 hours more at about 25° C., and then ?ltered
tion).
with suction. Benzene (50 ml.) was washed over the 35
Analysis.—Calculated for C14H22Cl-2N2O3: C, 49.86;
?lter cake into the ?ltrate. The resulting benzene solu
H, 6.58; N, 8.31. Found: C, 49.87; H, 6.28; N, 8.54. 9
Following the same procedure but substituting for the
tion was introduced into a 2-liter, 3-necked ?ask ?tted as
ethanolic hydrogen chloride an ethanolic solution of hy
above and the solution was cooled to 10° C. Ethanolic
hydrogen chloride, prepared by dissolving 55 g. of gase 40 drobromic, sulfuric, phosphoric, tartaric, citric, acetic, bu
tyric, quinic, and succinic acids, the corresponding hydro
ous hydrogen chloride in 200 ml. of ethanol cooled in an
ice-bath, was added dropwise with stirring to the cooled
bromide, sulfate, phosphate, tartrate, citrate, acetate, bu
tyrate, quinate, and succinate acid addition salts of a-[Z
benzene solution, the temperature of the reaction mixture
(1 -pyrrolidinyl)ethylamino] - 3,4 - dihydroxyacetophe
none were prepared.
being maintained at about 10° C. during the addition.
The resulting solid was recovered on a ?lter, washed with
500 ml. of ethanol and 250 m1. of ether, and dried, yield
ing 138 g. (52%) of ot-[2-(1-pyrrolidinyl)ethylamino]
PART B
3,4-dibenzyloxypropiophenone dihydrochloride having a
Preparation of a-{[Z-(I-Pyrrolidinyl)Ethylamino1
Methyl}Prot0catechz:yl Alcohol Dihydrochloride
melting point of 215° to 217° C.
Analysis.—Calculated for C29H36Cl2N2O3: C, 65.54;
H, 6.83; N, 5.27; Cl, 13.34. Found: C, 65.77; H, 6.68;
N, 5.54; Cl, 13.09.
50
A mixture consisting of 4.5 g. (0.013 mole) of a-[2-( 1
pyrrolidinyDethylamino] - 3,4 - dihydroxyacetophenone
dihydrochloride, 50 ml. of water, 0.1 ml. of hydrochloric
acid (37% concentration), and 0.1 g. of 10 percent pal
a-bromopropiophenone, the same a-[2-(1-pyrrolidiny1) 55 ladium-on-charcoal catalyst in a Parr hydrogenation ap
Following the same procedure but substituting 3,4
dibenzyloxy-a-ch1oropropy1ophenone for 3,4-dibenzyloxy
ethylamino]-3,4—dibenzyloxypropiophenone dihydrochlo
paratus was shaken with hydrogen at a pressure of 50
p.s.i. at about 25 ° C. After 2.5 hours 85 percent of the
ride was prepared.
theoretical amount of hydrogen had been taken up. The
mixture was ?ltered with suction, and the ?ltrate was evap
PART B
Preparation of a-{] -[2-(] -Pyrr0lidinyl ) Et‘hylamino] -
Ethyl}Protocatechuyl Alcohol Dihydrochloride
A mixture consisting of 53.15 g. (0.1 mole) of a-[Z-(l
pyrrolidinyl)ethylamino] - 3,4-dibenzyloxypropiophenone
60
orated to dryness under reduced pressure on a steam bath.
The cz-{ [2-( l-pyrrolidinyl ) ethylamino] methyl}protocate
chuyl alcohol dihydrochloride thus obtained as a white
solid was recrystallized from 185 ml. of 95 percent etha
nol. The compound had a melting point of about 188°
coal catalyst, 200 m1. of water, and 0.25 ml. of hydro 65 C. (with decomposition).
Following the same procedure but substituting the hy
chloric acid (37 % concentration) in a Parr hydrogena
drobromide, sulfate, phosphate, tartrate, citrate, acetate,
tion apparatus was shaken with hydrogen at a pressure
buty-rate, quinate, and succinate acid addition salts of a
of 50 p.s.i. at about 25° C. until hydrogen absorption
[2 - (1 - pyrrolidinyl)ethylamino - 3,4 - dihydroxyaceto
ceased. The mixture was ?ltered with suction, and the
?ltrate was concentrated under reduced pressure at 60° C. 70 phenone for a- [2-(l-pyrrolidinyl)ethylamino]-3,4-dihy
droxyacetophenone dihydrochloride, the corresponding hy
dihydrochloride, 3.0 g. of 10 percent palladium-on-char
on a water bath.
The viscous gum thus obtained was
dissolved in just enough boiling ethanol to complete solu
tion. This solution was chilled to 5° C. and held over
night at that temperature to effect crystallization. The
resulting crystalline a-{l-[Z-(l-pyrrolidinyDethylamino]
YI
-1
it
drobromide, sulfate, phosphate, tartrate, citrate, acetate,
butyrate, quinate, and succinate acid addition salts of a
{[2 - (1 - pyrrolidinyl)ethylamino]methyl}protocatechuyl
75 alcohol were prepared.
8,092,636
5
6
EXAMPLE 3
EXAMPLE 6
Preparation of a-{3-Methyl-1-[2-(1-PyrrolidinyI)-Ethyl
amino]Butyl}Protocatechayl Alcohol Dihydrochloride
Preparation of a-{I-[2-(I-Hexamethyleneimino)~Ethyl
amino]Ethyl}Protocatechuyl Alcohol Dihydrochloride
PART A
PART A
Preparation of a- [2-( J -Pyrr0lidinyl )Etlzylam inO] -3,4
DibenzyIoxy-y-Methylvalerophenone Dih Idroch loride
Following the procedure of Example 1, Part A, but sub
stituting 3,4-dibenzyloxy-a-bromoJy-methylvalerophenone
for 3,4-dibenzyloxy-a-bromopropiophenone, a-[2-(1-pyr
Preparation of‘ a-[Z - (I ~Hexamethyleneimino) -Ethyl
amino]-3,4-Dibenzyloxypropiophenone Dihydrochloride
10
rolidinyl)ethylamino] - 3,4 - dibenzyloxy - 7 - methyl
pyrrolidinyl)ethylamine, a - [2-( l-hexamethyleneimino)
valerophenone dihydrochloride was prepared.
ethylamino]-3,4-dibenzyloxypropiophenone dihydrochlo
PART B
Preparation of a-{3-Methyl-1-[2-(1-Pyrrolidinyl) -Ethyl
amino]Butyl}Protocatechuyl Alcohol Dihydrochloride
ride was prepared.
15
pyrrolidinyl)ethy1amino] - 3,4 - dibenzyloxypropiophe
amino]Ethyl}Protocatechuyl Alcohol Dihydrochloride
20
Following the procedure of Example 1, Part B, but sub
stituting
none dihydrochloride, a-{3-methyl-1-[2-(l~pyrrolidinyl)
ethylamino]butyl}protocatechuyl alcohol dihydrochloride
e - [2-(1-hexamethyleneimino)ethylamino]-3,4
dibenzyloxypropiophenone dihydrochloride for a a-[2-( l
pyrrolidinyl)ethylamino] - 3,4-dibenzyloxypropiophenone
dihydrochloride, a - {l-[2-( l-hexamethyleneimino)ethyl
was prepared.
EXAMPLE 4
PART B
Preparation of a-{I-[2-(1-Hexamethyleneimino)-Ethyl
Following the procedure of Example 1, Part B, but sub—
stitutin g a- [ 2-( l-pyrrolidinyl) ethylamino] -3,4-dibenzyl
oxy--y-methylvalerophenone dihydrochloride for a-[Z-(l
Following the procedure of Example 1, Part A, but sub
stituting 2-(l-hexamethyleneirnino)ethylamine for 2-(1
25
amino]ethyl}protocatechuyl alcohol dihydrochloride was
prepared.
Preparation of a-{l~[2-(2,2-Dimethyl - 1 - Pyrollidinyl)
Ethylamino]EthyI}Protocatechuyl Alcohol Dilzydro
EXAMPLE 7
chloride
PART A
Preparation of a-[2-(2,2-Dimethyl-I-Pyrrolidinyl)~Ethyl
amino]-3,4-Dibenzyloxypropiophenone Dihydrochloride
Ten thousand ( 10,000) scored tablets for oral use, each
30
containing 50 mg. of a-{1-[2-(l-pyrrolidinyDethyl
amino]ethyl}protocatechuyl alcohol dihydrochloride, are
prepared from the following types and amounts of in
gredients:
Following the procedure of Example 1, Part A, but sub—
stituting 2-(2,2-dirnethyl-l-pyrrolidinyl)ethylamine for 2
Grams
a - [2 - (2,2 ~dimethyl - 1
35 a - {1 - [2 - (l-pyrrolidinyl)ethylamino]ethyl}proto
pyrrolidinyl)ethylamino] - 3,4 - dibenzyloxypropiophe
catechuyl alcohol dihydrochloride __________ __
Starch U.S.P.
_
170
Talc U.S.P ________________________________ _-
130
(l - pyrrolidinyl)ethylamine,
none dihydrochloride was prepared.
PART B
Lactose U.S.P.
Preparation of a-{I-[2-(2,2-DimethyI-1-Pyrrolia'inyl)
Ethylamino]Ethyl}Prot0catechuyl Alcohol Dihydro
Ascorbic acid
Calcium stearate
chloride
Following the procedure of Example 1, Part B, but sub
stituting
a - [2-(2,2 - dimethyl - 1 - pyrrolidinyl)ethyl
amino] - 3,4 - dibenzyloxypropiophenone dihydrochloride
for
_ 2600
___
___
37
100
19.5
The ?nely powdered lactose and sucrose are mixed well
The wet mass is forced through an 8-mesh screen, dried at
120° F. in a forced-air oven, and then put through a
16-mesh screen. The remainder of the ingredients, in
a - [2 - (1 - pyrrolidinyl)ethylamino] - 3,4 - dibenzyl
?ne powder form‘, are mixed well and then mixed with the
The ?nal mixture is then com
pressed into tablets, which are administered at the rate of
1 to 2 tablets 1 to 4 times a day for the prevention of
premature labor.
We claim:
50 dried lactose granules.
EXAMPLE 5
Preparation of a~[] - (2 - Piperidinoethylamino) - Ethyl]
Protocatechuyl Alcohol Dihydrochloride
_
45 and the mixture is granulated with 10% starch paste.
oxypropiophenone dihydrochloride, a - {1 - [2 - (2,2 - di
methyl - 1 - pyrrolidinyl) - ethylamino]ethyl}protocate
chuyl alcohol dihydrochloride was prepared.
_..___
40 Sucrose powder U.S.P. _____________________ .._
55
PART A
1. Compound selected from the group consisting of
(1) a - {1 - [2-(l-alkyleneimino)ethylamino] alkyl}proto
catechuyl alcohol represented by the following structural
Preparation of a-(Z-Piperidinoethylamino)-3,4~
Dibenzyloxypropiophenone Dihydrochloride
formula
Following the procedure of Example 1, Part A, but sub 60
stituting Z-pipericlinoethylamine for 2-( l-pyrrolidinyl)
OH R
t
no
ethylamine, a-(Z-piperidinoethylamino)-3,4-dibenzyloxy
propiophenone dihydrochloride was prepared.
( CH a) m
|
cH-oE-NH-crrr-oHl-NAR:“HM,
V
HO
PART B
65
wherein R is selected from the group consisting of hydro
Preparation of a-[1~(2-Piperidinoethylamino)Ethyl]
gen and lower-alkyl of from 1 to 4 carbon atoms, inclu
Protocatechuyl Alcohol Dihydrochloride
sive, n is an integer from 4 to 6, inclusive, and m is an
integer from 0 to 2, inclusive; and (2) acid addition salts
Following the procedure of Example 1, Pant B, but sub 70 thereof.
stituting a-(2-piperidinoethylamino) - 3,4 - dibenzyloxy
2. a~{1-[2-( l-pyrrolidinyl )ethylamino] ethyl}protocate
propiophenone dihydrochloride for a-[2-(-pyrrolylidinyl)
ethylamino]-3,4~dibenzyloxypropionphenone dihydrochlo
chuyl alcohol dihydrochloride.
3. a-{ [2-( l-pyrrolidinyl)ethylamino] methyl} protocate
ride, a- [ 1-(Z-piperidinoethylamino)ethyl1protocatechuyl
chuyl alcohol dihydrochloride.
alcohol dihydrochloride was prepared.
4. Compound selected from the group consisting of
75
8,092,636
7
tophenone dihydrochloride.
7. a-{ 1- [2-( l-pyrrolidinyl )ethylamino] alkyl}protocate
represented by the following structural formula
O
R
(CHOm
B’OQg-cH-NH-CHr-CHPN/11.11:.”
chuyl alcohol acid addition salt according to claim 1.
5
V
B!
wherein R is selected from the group consisting of hydro 10
gen and lower-alkyl of from 1 to 4 carbon atoms, inclu
sive, R’ is selected from the group consisting of hydrogen
and benzyl, n is an integer from 4 to 6, inclusive, and m
is an integer from 0 to 2, inclusive; and (2) acid addition
15
salts thereof.
5. a-[Z ~ (l-pyrrolidinyDethylamino] -3,4—dibenzyloxy
propiophenone dihydrochloride.
8
6. ¢-[2-( l-pyrrolidinyl ) ethylamino] -3 ,4-dihydroxyace
(1) a - [2 -( l-alkyleneimino)ethylamino]a1kanophenone
8. a - [2 - (l-pyrrolidinyDethylamino]-3,4-dibenzyloxy
alkanophenone acid addition salt according to claim 4.
9. a - [2 - (1-pyrrolidinyl)ethylamino]-3,4-dihydroxyal
kanophenone acid addition salt according to claim 4.
References Cited in the ?le of this patent
UNITED STATES PATENTS
2,431,285
2,864,825
Suter et a1 ____________ __ Nov. 18, 1947
Heinzelman et al _______ __ Dec. 16, 1958
OTHER REFERENCES
Langecker et a1.: Naunyn Schmiedebergs Arch. Exptl.
P-athol, Pharmakol, vol. 226, pages 493-504 (1955).
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