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STUDY OF COMPLEXING
ABILITY OF HEDP WITH 188Re
V.M.Petriev, V.G.Skvortsov,
L.L. Bozadzhiev, L.P.Frolikova
Medical Radiological Research
Center RAMS, Obninsk, Russia
D ynam ic s of binding of
188
R e w ith H E D P at pH 2.7 at c onc e ntr a-
tion of H E D P 0.017-0.24 m M (V olum e of e luate of
188
R e 0.5-7.0 m l)
110
100
P ercen t
90
80
0,017 mM
70
0,024 mM
60
0,04 mM
0,06 mM
50
0,08 mM
40
0,12 mM
30
0,24 mM
20
10
0
0
30
60
90
120
150
180
210
240
270
300
330
360
390
Tim e, m in
188
E ffe c tive ne ss of binding of R e w ith H E D P at pH 2,7
in the r ange of tim e 0-360 m in
100
10 min
90
20 min
80
30 min
P ercen t
70
40 min
60
50 min
50
60 min
120 min
40
180 min
30
240 min
20
300 min
360 min
10
0
0,017
0,024
0,04
0,06
0,08
C o nc e ntra tio n o f H E D P , m M
0,12
0,24
D y na m ic s o f binding o f
188
R e w ith H E D P a t pH 3 .6 a t c o nc e ntr a -
tio n o f H E D P 0 .0 1 7 -0 .2 4 m M (V o lum e o f e lua te o f
188
R e 0 .5 -7 .0 m l)
110
100
90
0 ,0 1 7 mM
70
0 ,0 2 4 mM
P ercen t
80
0 ,0 4 mM
60
0 ,0 6 mM
50
0 ,0 8 mM
40
0 ,1 2 mM
30
0 ,2 4 mM
20
10
0
0
30
60
90
120
150
180
210
240
270
300
330
360
390
T im e , m in
188
E ffe c tive ne ss of binding of
R e w ith H E D P at pH 3.6
in the r ange of tim e 0-360 m in
110
10 min
100
20 min
90
30 min
80
40 min
70
P ercen t
50 min
60
60 min
50
120 min
40
180 min
30
240 min
20
300 min
10
360 min
0
0,017
0,024
0,04
0,06
0,08
C o nc e ntra tio n o f H E D P , m M
0,12
0,24
D ynam ic s of binding of
188
R e w ith H E D P at pH 6.7 at c onc e ntr a-
tion of H E D P 0.017-0.24 m M (V olum e of e luate
188
R e 0.5-7.0 m l)
100
Pe r c e nt
90
80
0 ,0 1 7 m M
70
0 ,0 2 4 m M
60
0 ,0 4 m M
50
0 ,0 6 m M
40
0 ,0 8 m M
30
0 ,1 2 m M
20
0 ,2 4 m M
10
0
0
30
60
90
120
150
180
210
Tim e, m in
E ffr c tive ne ss o f binding o f
240
188
270
300
330
360
390
R e w ith H E D P a t pH 6 .7
in the r a ng e o f tim e 0 -3 6 0 m in
100
1 0 min
90
2 0 min
80
3 0 min
4 0 min
P ercen t
70
5 0 min
60
6 0 min
50
1 2 0 min
40
1 8 0 min
30
2 4 0 min
20
3 0 0 min
10
3 6 0 min
0
0 ,0 1 7
0 ,0 2 4
0 ,0 4
0 ,0 6
0 ,0 8
C o nce ntra tio n o f H ED P, mM
0 ,1 2
0 ,2 4
Dynamics of binding of 188Re with HEDP dependig on pH of
reaction medium at concentration of HEDP 0.24 mM
(Volume of eluate of 188Re 0.5 ml)
110
100
90
Percent
80
70
pH 2.7
60
pH 3.6
50
pH 6.7
40
30
20
10
0
0
30
60
90
120 150 180 210 240 270 300 330 360 390
Time, min
Effectiveness of binding of 188Re with HEDP at different pH of
reaction medium at concentration of HEDP 0.24 mM
(Volume of eluate of 188Re 0.5 ml)
Percent
100
90
80
70
60
50
40
30
20
10
0
pH 2.7
pH 3.6
pH 6.7
1 min
10 min
20 min
30 min
40 min
50 min
60 min
120 min
180 min
240 min
300 min
360 min
Percent
Dynamics of binding of 188Re with HEDP dependig on pH of
reaction medium at concentration of HEDP 0.12 mM
(Volume of eluate of 188Re 1.0 ml)
110
100
90
80
70
60
50
40
30
20
10
0
pH 2.7
pH 3.6
pH 6.7
0
30
60
90
120
150
180
210
Time, min
240
270
300
330
360
390
Effectiveness of binding of 188Re with HEDP at different pH of
reaction medium at concentration of HEDP 0.12 mM
(Volume of eluate of 188Re 1.0 ml)
1 min
100
10 min
90
20 min
80
30 min
Percent
70
40 min
60
50 min
50
60 min
40
120 min
30
180 min
20
240 min
10
300 min
0
pH 2.7
pH 3.6
pH 6.7
360 min
Percent
Dynamics of binding of 188Re with HEDP dependig on pH of
reaction medium at concentration of HEDP 0.06 mM
(Volume of eluate of 188Re 2.0 ml)
110
100
90
80
70
60
50
40
30
20
10
0
pH 2.7
pH 3.6
pH 6.7
0
30
60
90
120
150 180
210 240
270 300 330
360 390
Time, min
188
E ffe c tive n e ss o f b in d in g o f
R e w ith H E D P a t d iffe r e n t p H o f
r e a c tio n m e d iu m a t c o n c e n tr a tio n o f H E D P 0 .0 6 m M
(V o lu m e o f e lu a te o f
188
R e 2 .0 m l)
100
1 min
P ercent
90
1 0 min
80
2 0 min
70
3 0 min
4 0 min
60
5 0 min
50
6 0 min
1 2 0 min
40
1 8 0 min
30
2 4 0 min
3 0 0 min
20
3 6 0 min
10
0
pH 2 .7
pH 3 .6
pH 6 .7
Dynamics of binding of 188Re with HEDP dependig on pH of reaction
medium at concentration of HEDP 0.04 mM
(Volume of eluate of 188Re 3.0 ml)
100
90
pH 2.7
80
pH 3.6
pH 6.7
60
50
40
30
20
10
0
0
30
60
90
120
150
180
210
240
270
300
330
360
390
Time, min
Effectiveness of binding of 188Re with HEDP at different pH of
reaction medium at concentration of HEDP 0.04 mM
(Volume of eluate of 188Re 3.0 ml)
100
1 min
10 min
20 min
30 min
40 min
50 min
60 min
120 min
180 min
240 min
300 min
360 min
90
80
70
Percent
Percent
70
60
50
40
30
20
10
0
pH 2.7
pH 3.6
pH 6.7
Dynamics of binding of 188Re with HEDP dependig on pH of reaction
medium at concentration of HEDP 0.024 mM
(Volume of eluate of 188Re 5.0 ml)
100
90
80
pH 2.7
pH 3.6
pH 6.7
60
50
40
30
20
10
0
0
30
60
90
120
150
180
210
Time, min
240
270
300
330
360
390
Effectiveness of binding of 188Re with HEDP at different pH of
reaction medium at concentration of HEDP 0.024 mM
(Volume of eluate of 188Re 5.0 ml)
90
1 min
80
10 min
70
20 min
60
Percent
Percent
70
30 min
50
40 min
40
50 min
60 min
30
120 min
20
180 min
10
240 min
300 min
0
pH 2.7
pH 3.6
pH 6.7
360 min
90
Dynamics of binding of 188Re with HEDP dependig on pH
of reaction medium at concentration of HEDP 0.017 mM
(Volume of eluate of 188Re 7.0 ml)
80
70
pH 2.7
pH 3.6
pH 6.7
50
40
30
20
10
0
0
30
60
90
120
150 180
210 240
Time, min
270 300 330
360 390
Effectiveness of binding of 188Re with HEDP at different pH of
reaction medium at concentration of HEDP 0.017 mM
(Volume of eluate of 188Re 7.0 ml)
1 min
10 min
20 min
30 min
40 min
50 min
60 min
120 min
180 min
240 min
300 min
360 min
80
70
60
Percent
Percent
60
50
40
30
20
10
0
pH 2.7
pH 3.6
pH 6.7
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