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RABIES VIRUS

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RABIES VIRUS
What’s this?
• Morphology and structure
• Replication
• Pathogenesis
• Clinical symptoms
• Diagnosis
• Prevention and Treatment
Morphology
• bullet-shaped;
• 45-100 nm in diameter; 100-430 nm long.
structure
• Core
•
•
Capsid
P-protein
Envelope
•
•
•
•
•
-ssRNA
L-protein (large protein)
---RNA dependent RNA polymerase
N-protein
---protect RNA from hydrolysis
Bilipid layer
M-protein (matrix protein)
G-protein (glucoprotein)
---spike
---bind to the receptor of the host cell
RNP
• Rabies is an RNA virus. The genome
encodes 5 proteins designated as N, P, M,
G, and L. The order and relative size of
the genes in the genome are shown in the
figure below. The arrangement of these
proteins and the RNA genome determine
the structure of the rabies virus.
•
Replication
• Adsorption
• Penetration
• Uncoating
• Biosynthesis
• Assembly and release
biosynthesis
•
•
•
•
•
•
-ssRNA
RNA polymerase
+ssRNA
-ssRNA
protein
virus
Pathogenesis
•
CNS
afferent fibers
nerve endings
Neuromuscular
junction
muscles
Virus
efferent fibers
salivary gland
organs and tissues
Clinical symptoms
• Early stage (1-3days)
•
fever(37.5-38)
•
vomit
•
wound:pain,red,itching
• Exciting stage(1-3days)
•
fever(39-40)
•
hydrophobia:pharyngeal muscle
cramp,dyspnea
•
dehydration
• Paralytic stage(15-20hs)
•
nerve fiber paralysis
•
respiratory and circulatory failure
death
Diagnosis
•
•
Pathogenic history
Isolating the dog(7-10days)
cerebral smear or slice
immunofluorescent stain
Prevention and treatment
• Kill wild dogs
• Keep away from
dogs
• Clean the wound
• Passive immunity
• vaccine
Contributers
• Bian Shu
• Cheng Wei
• Cong Ping
• Hu Chen
• Mu Xueru
• Li Yuntao
• Shao Cong
• Li Daowei
• Zhang Jingjing
• Wang Shengxi
• Zhu Wenying
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